Senior Scientist I, Biopharma Characterisation (MS/MS)

IMMUNOCORE LTD; Lower Swell; On-site; GBP 50,000 - 75,000; Full time

Job summary

Immunocore Ltd is seeking Senior Scientist I - Characterisation for CMC at the Oxford site. You will develop and apply peptide mapping (LC-MS/MS) and intact mass analysis to characterise biopharmaceuticals, supporting substance and product impurity analysis.

You will work with proteins expressed in microbial and mammalian systems, contribute to method development for ImmTAX products, write study protocols, and mentor junior staff while adhering to EHS standards.

Qualifications

• Experience in development of HPLC-based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experienced in assay development.

Responsibilities

• Characterise process intermediates and product impurities.
• Perform peptide mapping and intact mass analysis.
• Develop characterisation methods for ImmTAX and other products.
• Lead biochemical characterisation and stability studies.
• Contribute to study protocols and reports.
• Present findings to colleagues and partners.
• Maintain laboratory records and provide guidance on equipment use.

Skills

Mass spectrometry

Peptide mapping

Glycosylation analysis

Protein characterisation

Assay development

Mammalian expression

Stability studies

Education

BSc/ MSc in biochemistry or biotechnology

PhD in related discipline

Job description

Immunocore Ltd is seeking Senior Scientist I - Characterisation for CMC at the Oxford site. You will develop and apply peptide mapping (LC-MS/MS) and intact mass analysis to characterise biopharmaceuticals, supporting substance and product impurity analysis.

You will work with proteins expressed in microbial and mammalian systems, contribute to method development for ImmTAX products, write study protocols, and mentor junior staff while adhering to EHS standards.