Senior Scientist I, Biopharma Characterisation & MS

IMMUNOCORE LTD; Middle Aston; On-site; GBP 70,000 - 90,000; Full time

Job summary

Oxford Immunocore is seeking a Senior Scientist I - Characterisation within CMC to advance biopharmaceutical characterisation for TCR biologics. You will develop LC-MS/MS-based peptide mapping methods, perform mass spectrometric analysis, and contribute to glycosylation studies of recombinant proteins and antibodies.

This role requires bench work, data interpretation, and cross-functional collaboration. You will coordinate extensive testing, mentor peers, and help write study protocols and

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic, or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise drug substances and products using peptide mapping and mass spectrometry.
• Develop and perform analyses for process intermediates and product comparability.
• Lead method development and ensure data quality and records.
• Mentor colleagues and share knowledge across the department.
• Prepare study protocols and reports; present findings to stakeholders.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Recombinant proteins

Assay development

Biopharmaceutical stability

Team collaboration

Education

BSc or MSc in biochemistry/biotechnology

PhD in related discipline

Tools

LC-MS/MS

HPLC

Mass spectrometry instrumentation

Job description

Oxford Immunocore is seeking a Senior Scientist I - Characterisation within CMC to advance biopharmaceutical characterisation for TCR biologics. You will develop LC-MS/MS-based peptide mapping methods, perform mass spectrometric analysis, and contribute to glycosylation studies of recombinant proteins and antibodies.

This role requires bench work, data interpretation, and cross-functional collaboration. You will coordinate extensive testing, mentor peers, and help write study protocols and