Senior Scientist I - Biopharma Characterisation & MS

IMMUNOCORE LTD; North Leigh; On-site; GBP 65,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation in Oxford (CMC). You will develop and characterise biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis, working to advance ImmTAX products.

The role involves writing study protocols, data interpretation, and collaboration across teams in a bench-based biopharma setting. You will contribute to GMP/GLP studies, mentor peers, and present findings.

Qualifications

• BSc. or MSc. in biochemistry, biotechnology or related discipline.
• Desirable: PhD in related discipline.
• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Expertise in electrophoretic, chromatographic or mass spectrometry techniques.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
• Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department. May also act as a mentor to other colleagues, sharing scientific knowledge. Providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the department.
• Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
• Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively.
• Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
• Adhere to safe working practices in laboratories according to Immunocore EHS policies.

Skills

Peptide mapping

Mass spectrometry

HPLC

Protein characterisation

Assay development

Team collaboration

Mentoring

Data interpretation

Education

BSc or MSc in biochemistry/biotechnology

Desirable: PhD in related discipline

Tools

LC-MS/MS

Mass spectrometry equipment

Chromatography

Job description

Immunocore is seeking a Senior Scientist I - Characterisation in Oxford (CMC). You will develop and characterise biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis, working to advance ImmTAX products.

The role involves writing study protocols, data interpretation, and collaboration across teams in a bench-based biopharma setting. You will contribute to GMP/GLP studies, mentor peers, and present findings.