Senior Scientist, Biopharma Characterisation & MS

IMMUNOCORE LTD; Hale; On-site; GBP 70,000 - 95,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation in the CMC group (Oxford Immunocore). The role focuses on developing and applying LC-MS/MS and peptide mapping methods to characterise recombinant proteins and antibodies, including glycosylation analysis and PTMs, within a bench Biopharma setting.

You will coordinate extensive testing, interpret complex data, and contribute to study protocols and reports while collaborating across departments and mentoring teammates.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic, or mass spectrometry.
• Experienced in assay development
• Familiar with biopharmaceutical stability study principles and interpretation thereof
• Worked and contributed actively in a diverse team environment
• Proposed and driven changes in working practices that have improved efficiency
• Presented detailed scientific findings and papers to internal and external audiences

Responsibilities

• Characterise biologics and perform mass spectrometry analyses to support development programs.
• Lead method development for LC-MS/MS and peptide mapping of biopharmaceuticals.
• Collaborate across teams to interpret data and advance projects.
• Document and report experimental findings clearly and concisely.
• Mentor colleagues in analytical techniques as needed.
• Ensure compliance with EHS and quality standards.

Skills

HPLC peptide mapping

Mass spectrometry characterisation

Glycosylation analysis

Protein characterisation

Post-translational modifications

Assay development

Biopharmaceutical stability

Team collaboration

Education

BSc or MSc in biochemistry/biotechnology or related discipline

PhD in related discipline

Tools

LC-MS/MS

Chromatography systems

Job description

Immunocore is seeking a Senior Scientist I - Characterisation in the CMC group (Oxford Immunocore). The role focuses on developing and applying LC-MS/MS and peptide mapping methods to characterise recombinant proteins and antibodies, including glycosylation analysis and PTMs, within a bench Biopharma setting.

You will coordinate extensive testing, interpret complex data, and contribute to study protocols and reports while collaborating across departments and mentoring teammates.