Senior Biotech Scientist: Protein Characterisation & LC-MS

IMMUNOCORE LTD; Long Compton; Vor Ort; GBP 65.000 - 90.000; Vollzeit

Zusammenfassung

Oxford Immunocore is seeking a Senior Scientist I - Characterisation to join the CMC team in Oxford. You will lead peptide mapping and mass spectrometry workflows to characterise recombinant proteins and antibodies, and contribute to method development for ImmTAX programmes.

You will design experiments, interpret data, and author study protocols and reports while mentoring colleagues. A bench-based biopharma background and experience with glycosylation analysis and stability studies are

Qualifikationen

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic and mass spectrometry analyses.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and supported teams through adoption and change.
• Presented detailed scientific findings and papers to internal and external audiences.

Aufgaben

• Contribute to writing study protocols and reports.
• Independently testing and leading lines of investigation; propose new experiments based on data.
• Set priorities for own work and team projects guided by department goals.
• Share knowledge with the wider team and mentor colleagues.
• Maintain laboratory records up to date and ensure correct standards.
• Provide technical guidance on laboratory equipment usage.
• Report findings and present to meetings with colleagues and partners.
• Adhere to Immunocore EHS policies and safe working practices.

Kenntnisse

HPLC peptide mapping

Mass spectrometry characterisation

Glycosylation analysis

Protein biomolecules testing

Protein characterisation

Post-translational modifications

Biopharmaceutical lab experience

Electrophoretic analysis

Chromatographic analysis

Mass spectrometry

Assay development

Stability studies

Team collaboration

Process improvement

Scientific presentation

Ausbildung

BSc/MSc in Biochemistry/Biotechnology

PhD in related discipline

Tools

Jobbeschreibung

Oxford Immunocore is seeking a Senior Scientist I - Characterisation to join the CMC team in Oxford. You will lead peptide mapping and mass spectrometry workflows to characterise recombinant proteins and antibodies, and contribute to method development for ImmTAX programmes.

You will design experiments, interpret data, and author study protocols and reports while mentoring colleagues. A bench-based biopharma background and experience with glycosylation analysis and stability studies are