Senior Scientist I, Biologics Characterisation & MS

IMMUNOCORE LTD; Little Brickhill; On-site; GBP 65,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation to advance analytical methods for characterising biopharmaceuticals, including peptide mapping and intact mass analysis. You will work within the CMC group at Oxford, contributing to impurity characterisation, process development support, and cross-functional collaboration.

You will design and implement biochemical assays, mentor colleagues, and present findings to internal and external audiences, supporting STRIDE values and a

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry methods.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and supported teams through adoption and change.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Support impurity characterisation and identification of drug substance and drug product.
• Perform protein sequence and post-translational modification identification, including glycosylation analysis.
• Support process development by characterising process intermediates.
• Contribute to development of characterisation methods for ImmTAX and related products (LC-MS/MS, intact mass).
• Design and perform biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to study protocols and reports.
• Independently test and increasingly lead lines of investigation; propose new experiments.

Skills

Protein characterisation

Mass spectrometry

HPLC peptide mapping

Glycosylation analysis

Biopharma lab experience

Team collaboration

Project leadership

Data analysis

Education

BSc or MSc in biochemistry/biotechnology or related discipline

PhD in related discipline

Tools

LC-MS/MS

Job description

Immunocore is seeking a Senior Scientist I - Characterisation to advance analytical methods for characterising biopharmaceuticals, including peptide mapping and intact mass analysis. You will work within the CMC group at Oxford, contributing to impurity characterisation, process development support, and cross-functional collaboration.

You will design and implement biochemical assays, mentor colleagues, and present findings to internal and external audiences, supporting STRIDE values and a