Senior Scientist I, Biopharma Characterisation

IMMUNOCORE LTD; Upper Brailes; Presencial; GBP 55.000 - 75.000; Jornada completa

Descripción de la vacante

Immunocore is seeking a Senior Scientist I - Characterisation to advance characterisation methods for biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass analysis. You will work across bench science, develop assays, mentor colleagues, and contribute to protocol development in a dynamic, collaborative Biologics team in Oxford.

The role emphasizes independent investigation, data interpretation, and effective communication with senior management and partners, within a

Formación

• Essential: Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Essential: Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and supported teams through adoption and change.
• Presented detailed scientific findings and papers to internal and external audiences

Responsabilidades

• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation.
• Providing support on technical aspects to others.
• Laboratory records: ensuring records are up to date and correct.
• Laboratory equipment: providing technical guidance on equipment use.
• Reporting: communicating findings to meetings with colleagues and partners.
• Adhere to safety policies in laboratories.

Conocimientos

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein expression systems

Post-translational modifications

Assay development

Biopharmaceutical stability principles

Team collaboration

Educación

BSc or MSc in biochemistry/biotechnology

PhD in related discipline

Descripción del empleo

Immunocore is seeking a Senior Scientist I - Characterisation to advance characterisation methods for biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass analysis. You will work across bench science, develop assays, mentor colleagues, and contribute to protocol development in a dynamic, collaborative Biologics team in Oxford.

The role emphasizes independent investigation, data interpretation, and effective communication with senior management and partners, within a