Senior Scientist I, Biologics Characterisation (HPLC/MS)

IMMUNOCORE LTD; Little Kingshill; On-site; GBP 65,000 - 90,000; Full time

Job summary

IMMUNOCORE LTD is seeking a Senior Scientist I - Characterisation to join our CMC team in Oxford. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry methods to characterise biopharmaceutical products, including proteins and antibodies.

You will support impurity characterisation, PTM analysis, and development of characterisation methods for ImmTAX and related products, with opportunity to mentor colleagues and present findings to stakeholders.

Qualifications

• Experience in development of LC-MS/MS based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.

Responsibilities

• Characterise biopharmaceuticals including proteins and antibodies using LC-MS/MS and HPLC methods.
• Support drug substance/product impurity characterisation and identification.
• Perform glycosylation analysis and PTM identification.
• Contribute to development of characterisation methods for ImmTAX and related products.
• Design and conduct biochemical characterisation, chemical stability, and comparability studies.
• Assist in writing study protocols and reports.
• Present findings to internal and external audiences; mentor colleagues as needed.

Skills

Mass spectrometry

Peptide mapping

Biomolecule characterisation

Glycosylation analysis

Education

Bachelor's or MSc in Biochemistry/ Biotechnology

PhD in related discipline (Desirable)

Tools

LC-MS/MS

HPLC

Job description

IMMUNOCORE LTD is seeking a Senior Scientist I - Characterisation to join our CMC team in Oxford. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry methods to characterise biopharmaceutical products, including proteins and antibodies.

You will support impurity characterisation, PTM analysis, and development of characterisation methods for ImmTAX and related products, with opportunity to mentor colleagues and present findings to stakeholders.