Senior Scientist, Biopharma Characterisation (MS)

IMMUNOCORE LTD; Monks Risborough; Sur place; GBP 65 000 - 95 000; Plein temps

Avantages offerts par ce poste

Equal opportunity employer

Inclusive workplace

Résumé du poste

Senior Scientist I - Characterisation | CMC - Immunocore is a pioneering T cell receptor biotechnology company focused on developing next-generation biopharmaceuticals. The role involves developing and applying peptide mapping (LC-MS/MS) and mass spectrometry methods to characterise protein therapeutics, including glycosylation analysis, across microbial and mammalian expression systems.

You will contribute to development of characterisation methods for ImmTAX and other products, write study

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and supported teams.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsabilités

• Characterise drug substance and product using protein analytical methods.
• Develop and validate LC-MS/MS peptide mapping and intact mass analyses.
• Coordinate extensive testing of biomolecules across microbial and mammalian systems.
• Provide technical guidance on analytical methods and instrumentation.
• Present research findings to senior management and partners.
• Ensure proper laboratory records and compliance with EHS policies.
• Mentor colleagues and share knowledge across departments.

Connaissances

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Protein expression

Assay development

Stability studies

Team collaboration

Scientific reporting

Biopharmaceutical lab experience

Formation

BSc or MSc in biochemistry/ biotechnology or related

PhD in related discipline

Outils

LC-MS/MS

Mass spectrometry instrumentation

Description du poste

Senior Scientist I - Characterisation | CMC - Immunocore is a pioneering T cell receptor biotechnology company focused on developing next-generation biopharmaceuticals. The role involves developing and applying peptide mapping (LC-MS/MS) and mass spectrometry methods to characterise protein therapeutics, including glycosylation analysis, across microbial and mammalian expression systems.

You will contribute to development of characterisation methods for ImmTAX and other products, write study