Senior Scientist I: Biopharma Protein Characterisation & MS

IMMUNOCORE LTD; Newbold on Stour; On-site; GBP 60,000 - 85,000; Full time

Job summary

Senior Scientist I - Characterisation at Immunocore Ltd focuses on developing and applying protein characterisation methods to support Biopharmaceutical products. The role involves peptide mapping (LC-MS/MS), intact mass analysis, and glycosylation analysis of recombinant proteins or antibodies, with emphasis on process development and assay validation.

Oxford Immunocore is a pioneering biotech company working on T cell receptor therapies; the role requires bench-based expertise, collaboration

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic, or mass spectrometry techniques.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise drug substance and drug product using protein characterisation methods.
• Contribute to development of characterisation methods for biopharmaceutical products (peptide mapping, LC-MS/MS, intact mass).
• Design and perform biochemical characterisation and stability studies for biologics.
• Assist in writing study protocols and reports; present findings to teams and partners.
• Mentor colleagues and share knowledge across departments.
• Ensure laboratory records are up to date and compliant with EHS policies.
• Provide guidance on equipment use and maintenance to the team.
• Support and drive improvements in working practices and team efficiency.

Skills

Peptide mapping

Glycosylation analysis

Protein characterisation

Assay development

Team collaboration

Data interpretation

Education

BSc/ MSc in Biochemistry or Biotechnology

PhD (desirable)

Tools

LC-MS/MS

HPLC

Chromatography

Mass spectrometry data analysis

Job description

Senior Scientist I - Characterisation at Immunocore Ltd focuses on developing and applying protein characterisation methods to support Biopharmaceutical products. The role involves peptide mapping (LC-MS/MS), intact mass analysis, and glycosylation analysis of recombinant proteins or antibodies, with emphasis on process development and assay validation.

Oxford Immunocore is a pioneering biotech company working on T cell receptor therapies; the role requires bench-based expertise, collaboration