Senior Scientist I, Biologics Characterisation & MS

IMMUNOCORE LTD; Stony Stratford; On-site; GBP 55,000 - 75,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I in Characterisation within the CMC group in the UK. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry to characterise recombinant proteins and antibodies.

You will contribute to biopharmaceutical product characterisation methods and data interpretation, reporting findings to internal and external stakeholders. Experience with microbial and mammalian expression systems, PTM analyses, and stability principles

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic, or mass spectrometry methods.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that improved efficiency and adoption by teams.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Develop and apply peptide mapping (LC-MS/MS) and mass spectrometry for protein characterisation.
• Characterise glycosylation and PTMs of recombinant proteins/antibodies.
• Coordinate testing of protein biomolecules across projects.
• Contribute to development of characterisation methods for biopharmaceutical products.
• Prepare study protocols and reports; present findings to teams and partners.

Skills

HPLC peptide mapping

Mass spectrometry characterization

Glycosylation analysis

Protein expression systems (microbial;

Post-translational modification

Assay development

Biopharmaceutical stability knowledge

Independent testing coordination

Team collaboration

Technical mentoring

Education

BSc/MSc in Biochemistry/Biotechnology or related

PhD in related discipline

Tools

LC-MS/MS instruments

HPLC systems

Electrophoresis/Chromatography equipment

Job description

Immunocore is seeking a Senior Scientist I in Characterisation within the CMC group in the UK. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry to characterise recombinant proteins and antibodies.

You will contribute to biopharmaceutical product characterisation methods and data interpretation, reporting findings to internal and external stakeholders. Experience with microbial and mammalian expression systems, PTM analyses, and stability principles