Scientist 2

BioLegend, Inc.; Cambridge; On-site; GBP 30,000 - 40,000; Full time

Job summary

A leading life science company located in Cambridge is seeking a Scientist 2 to join their Preclinical Services Department. In this role, you will be responsible for planning and executing high-throughput compound screening and functional genomic projects. Candidates should have a higher-level degree in Biotechnology or related fields, strong mammalian cell culture skills, and experience with laboratory automation. The ideal candidate is highly motivated, flexible, and able to manage multiple projects effectively.

Qualifications

• Higher level degree in a relevant field with experience in mammalian cell culture.
• A good understanding of laboratory automation and liquid handling robots is preferred.
• Ability to communicate complex data effectively to stakeholders.

Responsibilities

• Plan and execute high-throughput compound screens.
• Design and analyze functional genomic screening projects.
• Collaborate with project management to provide excellent customer service.

Skills

Mammalian cell culture

Aseptic technique

Data handling and interpretation

Laboratory automation knowledge

Excellent communication skills

Organizational skills

Education

MSc, MRes or PhD in Biotechnology or Biological discipline

Tools

Lab information management systems (LIMS)

Graphpad Prism

Tibco Spotfire

Job description

Revvity (formerly Horizon Discovery), is a leading life science company that delivers science-driven research solutions advancing the understanding of the genetic basis of disease and the delivery of better healthcare outcomes for patients. We act as a discovery partner for leading pharma and biotech companies worldwide, providing research services and tools to support the development of personalized medicines.

Due to growth of our state-of-the-art Cell-Based Screening and Functional Genomic Screening Platforms, we have an exciting opportunity for a Scientist 2 to join our Preclinical Services Department. As a Scientist 2 in the Preclinical Services department, you will be responsible for planning, executing, and analysing data generated from high-throughput compound screens and CRISPR-Cas9 functional genomic screens for fee-paying commercial clients. You will also be involved with our automated robotics platforms for seeding, dosing and developing plate-based experiments. Your daily activities will directly align to and benefit Revvity’s goals and values.

This role will be primarily lab based, with some office work required. You will be expected to work on multiple tasks/projects simultaneously and should be highly self-motivated, able to work to tight timelines and be comfortable working under pressure in an environment with shifting priorities.

Note that this position requires flexible working to cover 7-day operations (rota-based). The possibility of weekend work is approximately once a quarter.

In this role you will:

• Contribute to the planning, execution and delivery of arrayed compound and pooled functional genomics screening projects.
• Design, QC and analyse screening projects, and manage screening activities - co-ordinating cell culture, compound management and automation scientists to ensure timely delivery of projects.

• Utilise our automated platform for seeding, dosing and developing plate-based assays, including developing our capabilities and endpoints further.

• Prepare client reports and support client project tracking and communication in collaboration with the project management office, maintaining an excellent customer experience from start to finish.
• Supervise more junior team members, mentoring them in techniques and troubleshooting.
• Contribute to continuous improvement of screening processes and workflows to maximise effectiveness and reduce costs.
• Work cross-functionally, collaborating for success with the wider Preclinical Services team and beyond.

About You

To succeed in this role, you will need:

• Higher level degree (e.g. MSc, MRes or PhD) in Biotechnology or Biological discipline (or equivalent experience).
• Experience of mammalian cell culture, excellent aseptic technique and performing various cell-based assays, such as those commonly employed at Revvity Cambridge (https://www.revvity.com/gb-en/category/preclinical-services).
• Experience of handling large datasets and the interpretation and communication of these data to key internal and external stakeholders.
• A familiarity with laboratory automation liquid handling robots, or a desire to learn about them.
• Experience with troubleshooting a variety of automation and instruments including Echo, Flexdrop, Nexus and Janus.

• Excellent interpersonal and communication skills, both written and verbal.

• Flexibility, adaptability, and ability to work in a dynamic matrix-managed team environment and on multiple projects with constantly changing priorities and deadlines.
• Excellent planning/organizational skills with a careful and meticulous nature.
• Ability to perform multiple tasks simultaneously, keep accurate records, follow and give instructions, and comply with company policies.

Preferred experience:

• Experience working in an Industrial / CRO setting.
• Experience with transfection, transduction and techniques to modulate gene expression in mammalian cell models e.g. CRISPR-Cas9, siRNA, shRNA etc.
• Safe handling and production of lentiviral reagents.
• Familiarity with data visualisation software such as Graphpad Prism and Tibco® Spotfire®.
• Knowledge of molecular biology techniques such as DNA extraction and PCR.
• Experience of high-throughput screening and knowledge of combination screening, including analysing and interpreting compound dose response experiments.
• Knowledge of lab information management systems (LIMS), liquid handling robotic equipment and laboratory automation (although full training will be provided).

• Experience with programming liquid handlers for a variety of different functions e.g. Janus.

• Compound handling experience varying from small molecules to biological materials (although full training will be provided).
• Experience of working in a customer-facing role.

If you have experience with CRISPR-Cas9, compound screening or laboratory automation and a keen interest in developing these skills further and applying these technologies to clinically relevant applications in a collaborative, team environment, to help our customers and aid drug-discovery then click on the link and apply below to start your screening journey with Revvity!