Biopharma Characterisation Scientist — MS & Glycosylation

IMMUNOCORE LTD; Little Faringdon; On-site; GBP 60,000 - 85,000; Full time

Job summary

Immunocore is a pioneering biopharmaceutical company focused on develop­ing soluble TCR therapies. The Senior Scientist I - Characterisation role supports CMC activities by advancing analytical methods such as LC-MS/MS peptide mapping and intact mass analysis for biologics and antibody workflows.

The role involves leading protein biomolecule analyses in microbial and mammalian systems, coordinating extensive testing, mentoring colleagues, and presenting findings to internal and external

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic, or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices to improve efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise drug substance and product by performing biochemical and analytical analyses.
• Develop and validate peptide mapping and mass spectrometry methods.
• Lead investigations and propose new experiments based on data.
• Maintain lab records, ensure safety, and mentor colleagues.
• Communicate findings to senior management and partners.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Assay development

Post-translational modifications

Education

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Tools

LC-MS/MS

HPLC

Mass spectrometry

Job description

Immunocore is a pioneering biopharmaceutical company focused on develop­ing soluble TCR therapies. The Senior Scientist I - Characterisation role supports CMC activities by advancing analytical methods such as LC-MS/MS peptide mapping and intact mass analysis for biologics and antibody workflows.

The role involves leading protein biomolecule analyses in microbial and mammalian systems, coordinating extensive testing, mentoring colleagues, and presenting findings to internal and external