Biopharma Characterisation Scientist I

IMMUNOCORE LTD; Seer Green; On-site; GBP 70,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation to advance analytical characterisation of biopharmaceuticals. You will perform peptide mapping, LC-MS/MS analyses and intact mass measurements to support development of ImmTAX and related products.

The role involves applying HPLC-based mapping, glycosylation studies and post-translational modification analysis, with responsibilities for protocol writing, data interpretation and collaboration across teams.

Qualifications

• Essential: Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Essential: Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise drug substance and drug product impurities.
• Perform protein sequencing and PTM identification incl. glycosylation analysis.
• Characterise process intermediates to support development.
• Contribute to peptide mapping (LC-MS/MS) and intact mass analysis methods.
• Design and perform biochemical characterisation, chemical stability and comparability studies of biologics.
• Contribute to study protocols and reports.
• Test and mentor others, analysing data to guide further experiments.
• Set priorities for own work and team projects based on overall goals.
• Share knowledge across the department and train colleagues.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein biomolecule testing

Protein expression (microbial & mammal

Post-translational mods

Analytical method development

SOPs and reports writing

Education

BSc or MSc in biochemistry/biotechnology

PhD in related discipline

Tools

LC-MS/MS

HPLC

Job description

Immunocore is seeking a Senior Scientist I - Characterisation to advance analytical characterisation of biopharmaceuticals. You will perform peptide mapping, LC-MS/MS analyses and intact mass measurements to support development of ImmTAX and related products.

The role involves applying HPLC-based mapping, glycosylation studies and post-translational modification analysis, with responsibilities for protocol writing, data interpretation and collaboration across teams.