Biologics Characterisation Scientist — LC-MS & Glycosylation

IMMUNOCORE LTD; Fenny Compton CP; On-site; GBP 70,000 - 100,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation to advance analytical methods for biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis. You will contribute to method development, support process development of biologics, and present findings in cross-functional teams.

You will work in an environment emphasising STRIDE values and collaboration, driving efficiency and sharing knowledge across the department.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.

Responsibilities

• Characterise proteins and biologics using LC-MS/MS and peptide mapping.
• Develop and validate analytical methods for protein characterization.
• Coordinate testing and interpret data to support CMC development.
• Collaborate across teams and present findings to stakeholders.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Biopharmaceutical lab experience

Education

BSc/MSc biochemistry

PhD desirable

Tools

LC-MS/MS

HPLC

Job description

Immunocore is seeking a Senior Scientist I - Characterisation to advance analytical methods for biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis. You will contribute to method development, support process development of biologics, and present findings in cross-functional teams.

You will work in an environment emphasising STRIDE values and collaboration, driving efficiency and sharing knowledge across the department.