Biopharma Characterisation Scientist I

IMMUNOCORE LTD

Stratfield Saye

On-site

GBP 55,000 - 75,000

Full time

3 days ago

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Job summary

Immunocore is seeking a Senior Scientist I - Characterisation within our CMC group in Oxford. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass-spectrometry based characterisation of recombinant proteins and antibodies.

You will work across teams to support drug substance and product development, assess stability, and contribute to study protocols and reports. A PhD is desirable; BSc/MSc required; strong protein analytical skills essential.

Qualifications

Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
Experience of glycosylation analysis of recombinant proteins or antibodies.
Independently coordinated extensive testing of protein biomolecules.
Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
Understanding of expected post-translational modifications in biological systems.
Worked in a bench-based biopharmaceutical laboratory environment.
Expert in electrophoretic, chromatographic or mass spectrometry techniques.
Experienced in assay development
Familiar with biopharmaceutical stability study principles and interpretation thereof
Worked and contributed actively in a diverse team environment
Proposed and driven changes in working practices that have improved efficiency
Presented detailed scientific findings and papers

Responsibilities

Supporting impurity characterisation and identification for drug substance and product.
Performing protein sequence and post translational modification identification, including glycosylation analysis.
Supporting development by characterising process intermediates.
Contribute to development of characterisation methods for ImmTAX and related products, including peptide mapping (LC-MS/MS) and intact mass analysis.
Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
Contribute to writing study protocols and reports.
Independently testing and, increasingly, leading lines of investigation; proposing new experiments based on emerging data and other related information.
Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project.
Technical Knowledge: sharing knowledge with the wider team and across departments; mentoring.
Laboratory records: ensuring records are up to date and compliant.
Laboratory equipment: providing technical guidance on equipment use.
Reporting: communicating findings at meetings with colleagues and management.
Adhere to safe working practices in laboratories per EHS policies.