Senior Scientist I: Biopharma Protein Characterisation

IMMUNOCORE LTD; Kingston Blount; Presencial; GBP 55.000 - 75.000; Jornada completa

Descripción de la vacante

Immunocore is recruiting a Senior Scientist I - Characterisation for its Oxford/CMC team. The role focuses on characterisation of biopharmaceuticals, including peptide mapping (LC-MS/MS), mass spectrometry, and glycosylation analyses to support drug substance/product development.

You will independently plan and execute experiments, mentor colleagues, prepare study reports, and contribute to improving working practices within a diverse team environment, in a GMP-aware setting.

Formación

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsabilidades

• Supporting drug substance and drug product impurity characterisation and identification
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation.
• Providing support on technical aspects to others.
• Priorities: establishing priorities for own work and team-based projects.
• Technical knowledge: sharing knowledge with the wider team and mentoring others.
• Laboratory records: ensuring records are up to date and well documented.
• Laboratory equipment: providing guidance on optimal use of equipment.
• Reporting: communicating and presenting research findings to colleagues and partners.
• Adhere to safe working practices in laboratories according to EHS policies.

Conocimientos

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Post-translational modifications

Biopharmaceutical knowledge

Assay development

Data interpretation

Team collaboration

Educación

BSc or MSc in biochemistry, biotechnology or related

PhD in related discipline

Herramientas

LC-MS/MS

HPLC

Mass spectrometry instrumentation

Descripción del empleo

Immunocore is recruiting a Senior Scientist I - Characterisation for its Oxford/CMC team. The role focuses on characterisation of biopharmaceuticals, including peptide mapping (LC-MS/MS), mass spectrometry, and glycosylation analyses to support drug substance/product development.

You will independently plan and execute experiments, mentor colleagues, prepare study reports, and contribute to improving working practices within a diverse team environment, in a GMP-aware setting.