Biopharma Characterisation Scientist I

IMMUNOCORE LTD; Lighthorne; On-site; GBP 55,000 - 75,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation to join our CMC group in the UK. You will lead biochemical and mass spectrometry characterisation of biopharmaceutical proteins, including peptide mapping and post-translational modification analyses, to support drug substance and product development.

You will coordinate testing campaigns, mentor colleagues, and contribute to study protocols and reports, while ensuring compliance with EHS and GMP principles in a bench-based biopharma

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Recombinant proteins

Assay development

Biopharma lab experience

Education

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Tools

LC-MS/MS

Mass spectrometry instruments

GMP familiarity

Job description

Immunocore is seeking a Senior Scientist I - Characterisation to join our CMC group in the UK. You will lead biochemical and mass spectrometry characterisation of biopharmaceutical proteins, including peptide mapping and post-translational modification analyses, to support drug substance and product development.

You will coordinate testing campaigns, mentor colleagues, and contribute to study protocols and reports, while ensuring compliance with EHS and GMP principles in a bench-based biopharma