Senior Scientist, Biopharma Characterisation (MS/Peptide)

IMMUNOCORE LTD; East Challow; On-site; GBP 70,000 - 100,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation to support and lead protein characterisation efforts for biologics, including peptide mapping and mass spectrometry analyses. You will work on glycosylation analysis, process development, and stability studies within a collaborative biopharmaceutical team.

Focused on driving method development, data integrity, and reporting, you will mentor peers, present findings, and help advance ImmTAX platforms through robust analytical work in a

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry techniques.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation.
• Providing support on technical aspects to others.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Assay development

Education

BSc/MSc in biochemistry/biotechnology

PhD (desirable)

Tools

LC-MS/MS

Mass spectrometry instrumentation

Job description

Immunocore is seeking a Senior Scientist I - Characterisation to support and lead protein characterisation efforts for biologics, including peptide mapping and mass spectrometry analyses. You will work on glycosylation analysis, process development, and stability studies within a collaborative biopharmaceutical team.

Focused on driving method development, data integrity, and reporting, you will mentor peers, present findings, and help advance ImmTAX platforms through robust analytical work in a