Senior Scientist I, Biopharma Characterisation

IMMUNOCORE LTD; Stanton St John; On-site; GBP 60,000 - 90,000; Full time

Job summary

Immunocore is a pioneering biopharma company focusing on biotherapeutics. We are seeking a Senior Scientist I - Characterisation to advance characterisation methods for our biopharmaceutical products, including LC-MS/MS peptide mapping and intact mass analysis.

The role involves supporting impurity characterisation, assay development, and collaboration across teams in a fast-paced lab environment. The ideal candidate has expertise in HPLC-based peptide mapping and mass spectrometry, with bench

Qualifications

• Experience developing HPLC-based peptide mapping methods.
• Glycosylation analysis of recombinant proteins or antibodies.
• Independent testing of protein biomolecules.
• Characterisation of proteins expressed in microbial and mammalian systems.
• Understanding post-translational modifications in biological systems.
• Bench-based biopharmaceutical laboratory experience.
• Expertise in electrophoretic, chromatographic, or mass spectrometry methods.
• Experience in assay development.
• Knowledge of GMP principles.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and leading lines of investigation; proposing new experiments based on data.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Education

BSc./MSc. in biochemistry/related

PhD in related discipline

Job description

Immunocore is a pioneering biopharma company focusing on biotherapeutics. We are seeking a Senior Scientist I - Characterisation to advance characterisation methods for our biopharmaceutical products, including LC-MS/MS peptide mapping and intact mass analysis.

The role involves supporting impurity characterisation, assay development, and collaboration across teams in a fast-paced lab environment. The ideal candidate has expertise in HPLC-based peptide mapping and mass spectrometry, with bench