Biopharma Characterisation Scientist I

IMMUNOCORE LTD; Over Worton; On-site; GBP 55,000 - 75,000; Full time

Job summary

Oxford Immunocore is seeking a Senior Scientist I - Characterisation within CMC to drive protein characterisation for biopharmaceuticals. The role involves LC-MS/MS-based peptide mapping, glycosylation analysis, and extensive protein biomolecule testing in a bench-based biopharma lab.

You will write protocols, generate reports, and mentor team members while collaborating across departments to advance ImmTAX and related biotherapeutics. The company emphasises STRIDE values and inclusive culture.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.

Responsibilities

• Characterise protein drugs using LC-MS/MS and related methods to support Biologics development.
• Develop and execute stability and comparability studies.
• Write study protocols and reports and present findings to team and partners.
• Lead testing lines and mentor colleagues; propose improvements.
• Ensure laboratory records are maintained and compliant with EHS and GMP parity.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Bench-based biopharma experience

Experiment design & troubleshooting

Independent testing & mentoring

Education

BSc or MSc in biochemistry/biotechnology or related

PhD (Desirable)

Tools

LC-MS/MS

HPLC

Job description

Oxford Immunocore is seeking a Senior Scientist I - Characterisation within CMC to drive protein characterisation for biopharmaceuticals. The role involves LC-MS/MS-based peptide mapping, glycosylation analysis, and extensive protein biomolecule testing in a bench-based biopharma lab.

You will write protocols, generate reports, and mentor team members while collaborating across departments to advance ImmTAX and related biotherapeutics. The company emphasises STRIDE values and inclusive culture.