Senior Scientist I - Biopharma Protein Characterisation

IMMUNOCORE LTD; Milton Common; On-site; GBP 55,000 - 75,000; Full time

Job summary

Senior Scientist I - Characterisation at Immunocore (CMC) in Oxford is responsible for developing and applying protein characterization methods, including peptide mapping (LC-MS/MS) and intact mass analysis, to support drug substance and product programmes.

You will work in a bench-based biopharmaceutical laboratory, coordinate extensive testing, mentor colleagues, and contribute to study protocols and reports while adhering to STRIDE values and EHS policies.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by characterisation of process intermediates.
• Contribute to the development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation and proposing new experiments.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on goals and evidence.
• Technical knowledge: sharing knowledge and mentoring; evaluating new techniques to advance the company.
• Laboratory records: ensuring records are up to date and accurate.
• Laboratory equipment: providing technical guidance on equipment use.
• Reporting: communicating and presenting findings to colleagues and management.
• Adhere to safe working practices in laboratories according to EHS policies.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Assay development

Team collaboration

Education

BSc or MSc in biochemistry/biotechnology

PhD (desirable)

Tools

HPLC

LC-MS/MS

Mass spectrometry

Electrophoresis

Job description

Senior Scientist I - Characterisation at Immunocore (CMC) in Oxford is responsible for developing and applying protein characterization methods, including peptide mapping (LC-MS/MS) and intact mass analysis, to support drug substance and product programmes.

You will work in a bench-based biopharmaceutical laboratory, coordinate extensive testing, mentor colleagues, and contribute to study protocols and reports while adhering to STRIDE values and EHS policies.