Senior Biologics Scientist: Protein Characterisation & MS

IMMUNOCORE LTD; High Wycombe; On-site; GBP 68,000 - 92,000; Full time

Job summary

Immunocore is recruiting a Senior Scientist I - Characterisation within the CMC team in the UK. The role focuses on characterising biologics and biopharmaceutical products using peptide mapping (LC-MS/MS), glycosylation analysis and mass spectrometry, supporting process development, and advancing methods.

You will author study protocols, generate reports, and mentor colleagues while collaborating across departments to drive project success and ensure high-quality data.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry methods.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise proteins and reagents using LC-MS/MS and related analytical methods.
• Develop and transfer characterisation methods for biopharmaceutical products.
• Write study protocols and reports to support CMC documentation.
• Mentor colleagues and share knowledge across the department.
• Prioritise tasks and drive project progress with evidence-based decisions.
• Present findings to senior management and external partners.

Skills

Peptide mapping

Glycosylation analysis

Protein characterisation

Post-translational modifications

Mass spectrometry

Chromatography

Electrophoresis

Assay development

Stability studies

Data presentation

Change management

Education

BSc./MSc in biochemistry/biotech or related

PhD in related discipline

Tools

LC-MS/MS

HPLC

Job description

Immunocore is recruiting a Senior Scientist I - Characterisation within the CMC team in the UK. The role focuses on characterising biologics and biopharmaceutical products using peptide mapping (LC-MS/MS), glycosylation analysis and mass spectrometry, supporting process development, and advancing methods.

You will author study protocols, generate reports, and mentor colleagues while collaborating across departments to drive project success and ensure high-quality data.