Senior Scientist I: Biologics Characterisation & MS Expert

IMMUNOCORE LTD; Castle Eaton; Sur place; GBP 70 000 - 90 000; Plein temps

Résumé du poste

Immunocore is seeking a Senior Scientist I - Characterisation to advance characterisation methods for biopharmaceuticals, including LC-MS/MS peptide mapping and intact mass analysis. You will conduct biochemical characterisation, stability studies, and contribute to study protocols, reports, and cross-functional collaboration in a fast-paced biopharma setting.

The role emphasizes independent testing, mentorship, data interpretation, and knowledge sharing across departments, aligning with STRIDE

Qualifications

• Experience in development of HPLC-based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and adoption across teams.
• Presented detailed scientific findings to internal and external audiences.

Responsabilités

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post-translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the development of characterisation methods for ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation.
• Providing support on technical aspects to others.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team.
• Technical knowledge: sharing knowledge with wider team; may mentor; providing analysis of new techniques.
• Laboratory records: ensuring documentation is up to date.
• Laboratory equipment: providing technical guidance on equipment use.
• Reporting: communicating and presenting research findings to meetings with colleagues and senior management.
• Adhere to safe working practices in laboratories according to EHS policies.

Connaissances

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein expression (microbial & mammal

Post-translational modifications

Assay development

Biopharma stability principles

Team collaboration

Data presentation

Analytical technique evaluation

Formation

BSc or MSc in biochemistry/biotechnology

Desirable: PhD in related discipline

Outils

HPLC

LC-MS/MS

Electrophoresis

Chromatography

Mass spectrometry instrumentation

Description du poste

Immunocore is seeking a Senior Scientist I - Characterisation to advance characterisation methods for biopharmaceuticals, including LC-MS/MS peptide mapping and intact mass analysis. You will conduct biochemical characterisation, stability studies, and contribute to study protocols, reports, and cross-functional collaboration in a fast-paced biopharma setting.

The role emphasizes independent testing, mentorship, data interpretation, and knowledge sharing across departments, aligning with STRIDE