offres d’emploi chez Linkedin à United States

Position : Pharmacologist- ADME / DMPK specialist / toxicology specialist

Experience Level : Ph.D. in Biochemistry / Biology / Cell Biology / Pharmacokinetics / Pharmacology or a related scientific field. Entry level to 5 years relevant industrial R&D experience.

Location : Remote (India, Philippines, Spain, Vietnam)

Company Description :

LegalForce RAPC Worldwide P.C. (parent law firm of Trademarkia) is expanding its Life Sciences practice to support clients developing cutting-edge pharmaceutical and AI-driven drug discovery innovations. We are building a specialized Pharmacology & AI-Driven Drug Development team.

With AI transforming pharmacokinetics (PK), pharmacodynamics (PD), and drug efficacy modeling, our clients need expert scientific support to secure strong patent protection, navigate regulatory pathways, and accelerate drug development.

Role Descriptions (2) :

1) ADME / DMPK specialist :

Seeking a scientist interested in the discovery and clinical development of medicines including small molecules, biologics / antibodies, peptides, ADCs, siRNAs, gene therapies, and other complex modalities. You will serve as a technical innovator in cross-functional teams to deliver novel therapies to patients. This role requires engaging in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We support one another through shared-learning and mutual-responsibility for the enterprise of making medicines.

You will :

• Innovate in a multidisciplinary collaborative environment with primary responsibility for ADME studies to support preclinical and clinical development of the client’s portfolio across modalities including small molecules, biologics / antibodies, peptides, ADCs, siRNAs, gene therapies and other complex modalities.
• Design and implement hypothesis driven studies to answer ADME, PK / PD and clinical pharmacology questions.
• Be accountable for the delivery of scientifically integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions.
• Partner with cross-functional colleagues in both Discovery and Development (eg. Toxicology, Pharmacology, Chemistry, Clinical PK / PD, Clinical Pharmacology, Regulatory, and Medical) to assess drugability and optimize ADME properties to deliver drug candidates to the clinic, as well as to design and support nonclinical and clinical studies supporting global registration packages.
• Integrate in vitro, in vivo, and in silico ADME data to define structure-activity and structure-property-relationships and deliver favorable molecular and experimental design strategies to guide drug delivery and optimization.
• Engage, innovate, and collaborate with colleagues and interdisciplinary teams.
• Lead the preparation of regulatory communication, patent applications, and documents to support clinical development, new drug applications (NDA and BLA) and line extensions and interact with regulatory agencies worldwide.
• Build and foster relationships through coaching and mentorship with fellow scientists.
• Possess excellent written and verbal technical communication and the ability to lead, guide and influence teams in decision making.

Additional Skills / Preferences :

• Experience with PK / PD modeling and / or biodistribution.
• Experience in drug discovery and development across a variety of therapeutic areas.
• Understanding of and experience with PCR, immunoassay, and / or LC / MS bioanalytical methodology.
• Detailed understanding of pharmacokinetics, ADME, drug interactions, and proficiency to communicate theory and concepts clearly.
• Experience with modeling software (e.g. SimCYP, GastroPlus, NONMEM, Matlab, etc.).
• Ability to balance multiple projects and handle competing responsibilities.
• Demonstrate strong communication skills with the ability to integrate diverse perspectives and to crisply deliver critical messaging.
• Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community.
• Experience authoring regulatory and technical reports.

A High-quality Candidate Will Demonstrate The Following :

• High learning speed and a keen ability to derive and efficiently test ADME, DMPK hypotheses and Toxicology.
• Strong working knowledge in fundamental pharmaceutics, pharmacokinetics and ADME principles across a variety of therapeutic modalities.
• Understanding of contemporary pharmaceutical regulatory guidance and expectations.
• Skills to integrate internal and external laboratory and other experimental resources through high quality scientific associations.
• Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and performance characteristics.

2) Toxicology specialist

Job responsibilities :

• Deeply understand the development goals of the project, as well as competition / clinical research / supervision / intellectual property / transformation and other cross-professional collaborative research needs, and deeply analyze the safety competition and positioning strategy of the project from the target disease field of the project. To comprehensively formulate the overall and current objectives of toxicology research, form the research framework and program points, and coordinate with the organization of resources and strength inside and outside the team to achieve the objectives and functions of professional research.
• Formulate and guide toxicology strategies from project initiation to product launch, supervise and guarantee the reliability, scientificity, rationality, efficiency and cost-benefit ratio of research results through the construction and improvement of internal procedure-standard-technical requirements and the guidance and review of toxicology research of specific projects.
• Plan and guide the technical capacity building of the toxicology research system and train toxicology professionals.
• Timely analyze and solve cross-team research problems, guide or collaborate with resources to solve difficult problems, conduct comprehensive discussions on stage results and form professional judgments, and put forward discussions and suggestions or reference for decision-making.
• Deep understanding of the technical principles and applications of the major, and creatively apply professional technologies to project-related special matters or cross-professional research support.
• Deeply understand the guidelines and practices of various American and European regulatory agencies for toxicology and safety research requirements of various products throughout the life cycle, formulate research strategies that meet regulatory needs, and coordinate with the drug administration to carry out international and domestic regulatory communication on toxicology.
• Review the evaluation and formulation of toxicology related content in the whole life cycle of external cooperation projects, and provide strategies and schemes for project initiation, introduction and development.
• Other key work related to toxicology system development and planning and project lifecycle toxicology.

Job Requirements :

• Doctor, major in pharmacology / pharmacy / Medicine / biology, with more than 10 years of continuous working experience in pharmaceutical companies or drug development biotech.
• More than 10 years of industry experience in innovative project-based drug toxicology research and 10 years of continuous experience in technical capacity building and project development.
• Experienced in the successful implementation of toxicological research strategies, plans and protocols at all stages of the entire life cycle (project initiation, discovery, IND, clinical and post-market) of innovative small molecule and biotechnology drugs.
• Deep understanding of toxicology in all stages of product research and development in various disease fields, and be able to establish and continuously improve the systematic capabilities of various research, including technical capacity building, research norms and templates, processes and systems.
• Deep understanding of drug administration regulations and guidelines related to toxicology and safety research of small molecule and biotechnology drugs in Europe and the United States, and the requirements of review practice; be competent in communicating with various planning and regulatory agencies; be able to integrate the requirements of toxicology and related professional drug administration registration into the research practice of toxicology team in a complete and in-depth way.
• Ability to use internal and external resources to lead the team to develop new technologies, new tools / methods, solve problems that cannot be solved by existing methods, create considerable project value and significantly reduce development risks.
• Participate in the formulation of industry rules and norms in the technical field, with domestic and international industry influence is preferred.
• Experience in small molecule, ADC, nucleic acid drugs and gene therapy is preferred.
• Experience in FDA review is preferred.
• The specific job rank will be determined according to the comprehensive qualifications of the candidate.

Why Join Us?

• Frontier of Innovation – Work at the intersection of pharmacology, AI, and pharmaceutical IP strategy.
• Growth Opportunity – Join an expanding Life Sciences patent and regulatory consulting practice.
• Global Collaboration – Work with leading biotech startups, pharma companies, and AI-driven drug development teams across India and the U.S.
• Competitive Compensation – Enjoy a highly competitive salary package, plus success-based bonuses.
• Impactful Work – Contribute to the development and patent protection of next-generation pharmaceuticals.

How to Apply

Please submit the following via LinkedIn :

Resume / CV with optional Cover Letter (single PDF) detailing your experience in pharmacology, AI-driven drug discovery, and scientific writing.

Representative Publications or writing samples showcasing your expertise.