Senior Scientist, Non-Viral LNP Process Sciences

Bristol-Myers Squibb Co; Cambridge (MA); On-site; USD 128,000 - 156,000; Full time

Job summary

Bristol-Myers Squibb Co. in Cambridge, MA, seeks a Scientist, Non-Viral Delivery Process Sciences to advance targeted LNP platforms through mechanistic process science and scalable manufacturing strategies.

You will work at the interface of formulation, conjugation, purification, and downstream processing with emphasis on robustness and collaboration. The role requires a PhD or equivalent in Life Sciences, hands-on LNP experience, and strong technical communication.

Qualifications

• Bachelor’s Degree and 5+ years of academic and/or industry experience.
• Master’s Degree and 3+ years of academic and/or industry experience.
• Ph.D. or equivalent advanced degree in the Life Sciences.
• No experience necessary.

Responsibilities

• Design and execute hypothesis-driven studies to deepen mechanistic understanding and enable robust, scalable manufacturing approaches for targeted LNP platforms.
• Develop end-to-end targeted LNP processes spanning formulation, bioconjugation, purification, and downstream processing, with a focus on scalability, manufacturability, and process robustness.
• Establish mechanistic process understanding of targeting moiety conjugation and incorporation and how these processes influence product quality attributes.
• Develop and apply fit-for-purpose scale-down models to support process understanding, sensitivity analysis, and translation to larger-scale manufacturing.
• Apply design of experiments, statistical analysis, and analytical, biophysical, and functional characterization to establish process–attribute–performance relationships.
• Partner with Analytical Development to evaluate and implement process analytical technologies to strengthen real-time process understanding.
• Identify, evaluate, and implement emerging process technologies and experimental approaches that advance targeted LNP development and improve process efficiency, scalability, robustness, and manufacturability.
• Collaborate cross-functionally across Research, Process Development, Analytical Sciences, CMC, and external partners to translate early process understanding into scalable, development-ready manufacturing approaches.
• Document and communicate scientific findings through protocols, technical reports, presentations, and multidisciplinary forums.

Skills

LNP formulation

DoE (Design of Experiments)

Statistical analysis

Multidisciplinary collaboration

Technical communication

Biophysical characterization

Education

PhD in Life Sciences

Master's degree in Life Sciences

Bachelor's degree in Life Sciences

Tools

HPLC

LC/MS

DLS

UF/DF

Zeta potential

Job description

Bristol-Myers Squibb Co. in Cambridge, MA, seeks a Scientist, Non-Viral Delivery Process Sciences to advance targeted LNP platforms through mechanistic process science and scalable manufacturing strategies.

You will work at the interface of formulation, conjugation, purification, and downstream processing with emphasis on robustness and collaboration. The role requires a PhD or equivalent in Life Sciences, hands-on LNP experience, and strong technical communication.