LNP Process Development Scientist

Commonwealth Sciences, Inc.; Boston (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Commonwealth Sciences, Inc. is seeking an Associate Scientist/ Scientist to drive LNP process development for preclinical programs.

You will independently plan and execute lab studies, optimize LNP formulations and scale-up, and collaborate with internal and external partners to ensure timely data generation and delivery. The role requires strong hands-on experience with nanoparticle characterization, robust experimental design, and clear technical communication to cross-functional teams;

Qualifications

• BS/MS/PhD in Bioengineering, Chem Eng, Chemistry, Materials Science, Biochemistry, Biology or related with 3+ years industry lab experience.
• Hands-on experience in LNP, liposome or polymeric nanoparticle formulation and process development.
• Experience with nanoparticle characterization and analytical methods.
• Strong experimental design, data analysis, troubleshooting and documentation.

Responsibilities

• Independently plan, conduct, analyze, and troubleshoot lab studies with sound scientific judgment.
• Develop and optimize LNP formulations and process scale-up for preclinical research.
• Evaluate LNP quality attributes including encapsulation, size, PDI, zeta potential, ligand attachment, and related parameters.
• Prepare, characterize, and monitor LNP materials to support internal programs and cross-functional studies.
• Contribute to analytical method development and qualification for CQAs of drug substances/products.
• Collaborate with internal scientists and external partners to support in vitro/in vivo LNP studies and data delivery.
• Communicate results and conclusions through technical presentations to cross-functional teams and leadership.
• Support technology transfers to external CDMOs/CROs and preparation of regulatory documentation.

Skills

Experimental design

Data analysis

Troubleshooting

Project planning

Mentorship

Education

BS/MS/PhD in Biology/Engineering or related field

Tools

RiboGreen

DLS

PALS

SEC

IP-RP LC

Flow NanoAnalyzer

BCA/microBCA

Job description

Commonwealth Sciences, Inc. is seeking an Associate Scientist/ Scientist to drive LNP process development for preclinical programs.

You will independently plan and execute lab studies, optimize LNP formulations and scale-up, and collaborate with internal and external partners to ensure timely data generation and delivery. The role requires strong hands-on experience with nanoparticle characterization, robust experimental design, and clear technical communication to cross-functional teams;