Senior Scientist: Innate Immunity & Bioanalytical Assays

Pioneering Medicines; Cambridge (MA); On-site; USD 126,000 - 182,000; Full time

Job summary

Serif Biomedicines in Cambridge, MA, seeks a Senior Scientist, Bioanalytical Sciences, to lead immunogenicity and bioanalytical assay development for innate immunity and nucleic acid therapies. You will direct LBA and flow cytometry workflows, mentor junior scientists, and collaborate across CMC, molecular biology, and cell biology teams to deliver high-quality data for preclinical programs.

This is a hands-on, lab-based, fast-paced environment.

Qualifications

• Ph.D. in immunology, biochemistry, pharmaceutical sciences, cell biology or related field with 5+ years of industry experience.
• Demonstrated expertise in innate immune signaling and nucleic acid sensing pathways for DNA and mRNA.
• Proficiency in multicolor flow cytometry, ddPCR, ligand binding assays, leukopak processing and isolation of PBMCs.
• Experience with LNPs, and nucleic acid modalities preferred.
• Experience developing bioanalytical methods to measure drugs and biomarkers for LNP delivery of nucleic acid cargoes.
• Experience managing junior scientists.
• Strong communication, presentation and interpersonal skills.
• Attention to detail, strategic thinking, problem solving, and decision-making skills.

Responsibilities

• Design, develop and execute cell-based immunoassays, flow cytometry based assays and LBAs to assess immunogenicity to LNP delivered nucleic acid cargoes in vitro and in vivo.
• Apply knowledge of innate immunology and establish in vitro screening assays for various nucleic acid modalities and establish criteria for release of cargo for pre-clinical research.
• Collaborate with CMC, molecular biology and cell biology teams to screen nucleic acid cargoes and ensure timely data delivery.
• Ensure development, qualification, and validation of bioanalytical assays in compliance with guidelines.
• Design, optimize, and execute biodistribution studies for LNP/nucleic acid therapies.
• Design, establish and execute assays for immunogenicity predictors in rodents and NHPs.
• Develop and execute bioanalytical assays to support nonclinical studies (PK, PD, biomarkers).
• Execute test procedures (Flow Cytometry, ELISA, MSD, Luminex, ddPCR) and interpret data.
• Maintain documentation and present data at project meetings.
• Mentor, coach, and manage junior scientists.

Skills

Innate immunology

Flow cytometry

ddPCR

Ligand binding assays

Leadership / mentoring

Bioanalytical methods

Communication

Nucleic acid modalities

Education

Ph.D. in immunology / biosciences

Tools

Flow cytometry instruments

LBA platforms

PBMC isolation

LNP formulation knowledge

Job description

Serif Biomedicines in Cambridge, MA, seeks a Senior Scientist, Bioanalytical Sciences, to lead immunogenicity and bioanalytical assay development for innate immunity and nucleic acid therapies. You will direct LBA and flow cytometry workflows, mentor junior scientists, and collaborate across CMC, molecular biology, and cell biology teams to deliver high-quality data for preclinical programs.

This is a hands-on, lab-based, fast-paced environment.