Bioanalytical Assays Scientist, Nucleic Acid Therapeutics

Serif Biomedicines, Inc.; Cambridge (MA); On-site; USD 96,000 - 127,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Job summary

Serif Biomedicines, Inc. is seeking an Associate Scientist to drive bioanalytical assays for a novel DNA platform in a fast-paced biotech setting in Cambridge, MA.

You will handle in vitro and in vivo assays, bringing rigor, curiosity, and innovation to nucleic acid therapeutics development, collaborating across a multidisciplinary team. The role demands strong experience with ELISA, qPCR, ddPCR, and flow cytometry, plus tissue/cell processing skills.

Qualifications

• Masters or BS in relevant discipline with 6+ years of industry experience.
• Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, ddPCR.
• Hands-on experience with multi-parameter flow-cytometry, including panel design, compensation, and analysis.
• Experience with transfection methods in human and NHP PBMCs is preferred.
• Proficiency in processing tissues and isolation of various cell types from mice and NHPs.
• Prior experience in nucleic acid therapeutics or LNPs is a plus.
• Experience with histological techniques (IHC/ISH, H&E, etc.) analysis is a plus.

Responsibilities

• Execution and analysis of bioassays to assess efficacy, safety and biodistribution of nucleic acid therapeutics in rodents and NHPs.
• Contribute to scientific and technical perspectives to advance platform development.
• Develop, optimize, and execute ligand binding assays to support studies in-house and at CROs.
• Communicate experimental findings in oral, written, and visual formats.
• Work independently and collaboratively in a multidisciplinary team environment.

Skills

Bioassays

Flow cytometry

qPCR/ddPCR

Transfection in PBMCs

Tissue isolation

IHC/ISH

Data analysis

Education

MS/BS in relevant discipline

Tools

Flow cytometer

qPCR instruments

Job description

Serif Biomedicines, Inc. is seeking an Associate Scientist to drive bioanalytical assays for a novel DNA platform in a fast-paced biotech setting in Cambridge, MA.

You will handle in vitro and in vivo assays, bringing rigor, curiosity, and innovation to nucleic acid therapeutics development, collaborating across a multidisciplinary team. The role demands strong experience with ELISA, qPCR, ddPCR, and flow cytometry, plus tissue/cell processing skills.