Bioanalytical Scientist, Nucleic Acid Therapeutics

Pioneering Medicines; Cambridge (MA); On-site; USD 96,000 - 127,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Job summary

Serif Biomedicines in Cambridge, MA is seeking an experienced Associate Scientist to drive bio-analytical assays for a novel DNA platform. The role involves working with in vitro and in vivo assays, applying rigorous scientific methods, and collaborating across a fast-paced, entrepreneurial team.

You will execute and optimize assays (ELISA, qPCR, ddPCR), contribute to platform development, and communicate results clearly.

Qualifications

• Masters or BS in a relevant discipline with 6+ years of industry experience.
• Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, ddPCR.
• Hands-on experience with multi-parameter flow cytometry, including panel design, compensation, and analysis.
• Experience with transfection methods in human and NHP PBMCs.
• Proficiency in processing tissues and isolation of various cell types (hepatocytes, immune cells etc.) from mice and NHPs.
• Prior experience in nucleic acid therapeutics or LNPs is a plus.
• Experience with histological techniques (IHC/IF, ISH, H&E).
• Strong communication, interpersonal, organizational, analytical, and problem-solving skills.

Responsibilities

• Execute and analyze bioassays to assess efficacy, safety and biodistribution in rodents and NHPs.
• Contribute to scientific and technical perspectives to advance platform development.
• Develop, optimize, and execute ligand binding assays for studies in-house and at CROs.
• Communicate experimental findings orally, in writing, and visually.
• Work independently and in a multidisciplinary team.

Skills

Bioanalytical assays

ELISA

MSD

qPCR

ddPCR

Flow cytometry

PBMC transfection

Tissue processing

Nucleic acid therapeutics

Histology techniques

Communication skills

Team collaboration

Education

Master's or BS in a relevant discipline

Job description

Serif Biomedicines in Cambridge, MA is seeking an experienced Associate Scientist to drive bio-analytical assays for a novel DNA platform. The role involves working with in vitro and in vivo assays, applying rigorous scientific methods, and collaborating across a fast-paced, entrepreneurial team.

You will execute and optimize assays (ELISA, qPCR, ddPCR), contribute to platform development, and communicate results clearly.