Senior Manufacturing Operations Leader – 2nd Shift

Vertex Pharmaceuticals LLC; Boston, Northern (MA, KY); Hybrid; USD 139,000 - 209,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Comprehensive benefits

Generous paid time off

Commuting subsidy

Job summary

Vertex Pharmaceuticals LLC is seeking a Senior Manager of Manufacturing Operations for 2nd shift in Boston, MA. The role leads a supervisory team to ensure safe, compliant, and efficient cGMP manufacturing, aligning with production schedules and site priorities.

Responsibilities include directing staff, managing batch documentation, and driving continuous improvement while maintaining audit readiness and supporting validation, CAPA, and change control activities.

Qualifications

• Bachelor’s degree in a scientific, technical, or engineering discipline.
• Typically requires 10+ years of experience or the equivalent combination of education and experience.
• Strong experience in direct people supervision in a cGMP manufacturing environment.
• Significant leadership experience in pharmaceutical manufacturing operations within a cGMP-regulated environment.
• Prior cell therapy and aseptic manufacturing experience.

Responsibilities

• Manage and develop a supervisory team, ensuring strong execution and accountability.
• Direct activities of the group through staff management, prioritization, and task assignment.
• Provide departmental and technical leadership aligned with site leadership.
• Lead interdisciplinary projects and ensure production schedules and business needs are met.
• Oversee cGMP manufacturing activities, including equipment setup, cleaning, and batch documentation review.
• Participate in investigations, CAPAs, deviation management, and change control.
• Support validation activities, facility readiness, and manufacturing objectives.
• Maintain audit-ready status through procedures, documentation, and inspection readiness.

Skills

Leadership/people management

cGMP knowledge

DoE

QbD

SPC

Problem-solving

Communication

Education

Bachelor’s degree in a scientific/technical/engineering discipline

Tools

POMS MES

QDoCCS GMP systems

Job description

Vertex Pharmaceuticals LLC is seeking a Senior Manager of Manufacturing Operations for 2nd shift in Boston, MA. The role leads a supervisory team to ensure safe, compliant, and efficient cGMP manufacturing, aligning with production schedules and site priorities.

Responsibilities include directing staff, managing batch documentation, and driving continuous improvement while maintaining audit readiness and supporting validation, CAPA, and change control activities.