Night Shift Manufacturing Supervisor - GMP Operations

Vertex Pharmaceuticals LLC; Boston (MA); Hybrid; USD 98,000 - 147,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Overtime pay eligibility

Job summary

Vertex Pharmaceuticals LLC is seeking a Supervisor of Manufacturing Operations for the 3rd shift in Boston, MA. The role leads overnight manufacturing activities, assigns work per schedules, and ensures compliant cGMP operations including batch records and on-the-floor reviews.

You will supervise shift personnel, maintain audit readiness, and partner with QA to ensure SOP adherence and training. A 90‑day onboarding is included with potential schedule flexibility for onboarding and training.

Qualifications

• Bachelor’s degree in a scientific, technical or engineering discipline.
• 6+ years of experience or the equivalent combination of education and experience.
• Prior supervisory or leadership experience preferred.
• Prior cell therapy and aseptic manufacturing experience preferred.
• Prior POMS MES experience preferred.

Responsibilities

• Lead and supervise daily manufacturing operations across shifts.
• Assign work to shift personnel based on production plans and schedules.
• Oversee cGMP manufacturing activities, including equipment setup, operation, and cleaning.
• Execute and witness batch record instructions to ensure compliant documentation.
• Maintain audit-ready facility by adherence to procedures and SOPs; participate in training.

Skills

Leadership

Coaching

Communication

Prior supervisory experience

Education

Bachelor's degree in scientific/engineering

Tools

POMS MES

Job description

Vertex Pharmaceuticals LLC is seeking a Supervisor of Manufacturing Operations for the 3rd shift in Boston, MA. The role leads overnight manufacturing activities, assigns work per schedules, and ensures compliant cGMP operations including batch records and on-the-floor reviews.

You will supervise shift personnel, maintain audit readiness, and partner with QA to ensure SOP adherence and training. A 90‑day onboarding is included with potential schedule flexibility for onboarding and training.