Manufacturing Operations Supervisor - cGMP Lead

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 98,000 - 147,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

Paid time off

Commuting subsidy

401(k)

Job summary

Vertex Pharmaceuticals is seeking a Supervisor, Manufacturing Operations to lead first, second, or third-shift manufacturing activities in its Boston facility. You will assign work, ensure cGMP compliance, supervise shift personnel, and coordinate with QA and cross-functional teams to meet production plans.

This on-site role follows a daytime schedule with onboarding, training and opportunities to drive continuous improvement, safety, and inspection readiness.

Qualifications

• Bachelor's degree in a scientific, technical or engineering discipline.
• 6+ years of experience or the equivalent combination of education and experience.
• Prior supervisory or leadership experience preferred.
• Prior cell therapy and aseptic manufacturing experience preferred.
• Prior POMS MES experience preferred.

Responsibilities

• Lead and supervise daily manufacturing operations.
• Assign work to shift personnel based on detailed production schedules and operational plans.
• Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning.
• Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation.
• Performs real-time on the floor batch record review.
• Interface with cross-functional teams to support facility operations, maintenance activities, and manufacturing objectives.
• Monitor and enforce GMP compliance for all personnel and activities within the Drug Product facility.
• Maintain the facility in an audit-ready state through adherence to procedures, documentation standards, and inspection readiness practices.
• Ensure compliance with SOPs, policies, and work instructions to support safe and successful facility operation.
• Work with QA Document Control to request, receive, and return MBRs for process operations.
• Demonstrate Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking.
• Maintain personal and team compliance with all ongoing training requirements.
• Leading and Attending Tier 0 and Tier 1 meetings.
• Perform other duties and projects as assigned to meet departmental requirements.

Skills

Leadership

Coaching

Communication

Organization

cGMP knowledge

Procedural clarity

Cross-functional

Training compliance

Education

Bachelor's degree in science/engineering

6+ years experience

Supervisory/leadership experience

Cell therapy experience

POMS MES experience

Tools

POMS MES

Job description

Vertex Pharmaceuticals is seeking a Supervisor, Manufacturing Operations to lead first, second, or third-shift manufacturing activities in its Boston facility. You will assign work, ensure cGMP compliance, supervise shift personnel, and coordinate with QA and cross-functional teams to meet production plans.

This on-site role follows a daytime schedule with onboarding, training and opportunities to drive continuous improvement, safety, and inspection readiness.