Senior Manufacturing Operations Lead - 3rd Shift

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 139,000 - 209,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Job summary

Vertex Pharmaceuticals LLC in Boston, MA is seeking a Senior Manager, Manufacturing Operations for the 3rd shift to lead a supervisory team and ensure safe, compliant cGMP manufacturing aligned with schedules and business priorities.

You will drive continuous improvement, mentor leaders, and maintain an audit-ready facility while partnering cross-functionally on validation, investigations, and CAPA programs.

Qualifications

• Bachelor’s degree in a scientific, technical, or engineering discipline.
• 10+ years of experience in cGMP pharmaceutical manufacturing with supervision.
• Experience managing supervisors and cell therapy/aseptic manufacturing preferred.
• Strong leadership and regulatory compliance expertise.

Responsibilities

• Lead and develop a supervisory team, ensuring strong execution and accountability.
• Direct group activities through staffing, prioritization, and task assignment.
• Align with site leadership to provide departmental and technical leadership.
• Serve as project leader for departmental/interdisciplinary projects.
• Ensure production schedules are prioritized and executed to meet business needs.
• Oversee cGMP manufacturing activities, including equipment setup and cleaning.
• Review and approve batch documentation and GMP records.
• Oversee on-the-floor batch record review and escalate issues as needed.
• Participate in investigations, CAPAs, and change controls.
• Support validation activities, facility readiness, and manufacturing objectives.
• Maintain audit readiness through procedures and documentation standards.

Skills

Leadership

cGMP knowledge

Manufacturing operations

DoE

SPC

QbD

Education

Bachelor’s degree in science/engineering

Tools

POMS MES

QDoCCS

Job description

Vertex Pharmaceuticals LLC in Boston, MA is seeking a Senior Manager, Manufacturing Operations for the 3rd shift to lead a supervisory team and ensure safe, compliant cGMP manufacturing aligned with schedules and business priorities.

You will drive continuous improvement, mentor leaders, and maintain an audit-ready facility while partnering cross-functionally on validation, investigations, and CAPA programs.