Manufacturing Operations Lead – cGMP & Batch Ops (Shift)

Vertex Pharmaceuticals Incorporated; Boston (MA); On-site; USD 98,000 - 147,000; Full time

Job summary

Vertex Pharmaceuticals Incorporated in Boston, MA seeks a Supervisor of Manufacturing Operations to lead first, second, or third-shift activities, assign work per schedules, and ensure compliant daily cGMP operations including equipment setup, assembly, operation and cleaning. The role supervises shift personnel and enforces documentation integrity.

The position requires a Bachelor's in a scientific/technical field and 6+ years' experience with supervisory background; prior cell therapy and POMS

Qualifications

• Bachelor's degree in a scientific, technical or engineering discipline.
• 6+ years of experience in manufacturing or related roles.
• Prior supervisory or leadership experience.
• Prior cell therapy and aseptic manufacturing experience preferred.
• Prior POMS MES experience preferred.

Responsibilities

• Lead and supervise daily manufacturing operations.
• Assign work to shift personnel based on detailed production schedules and operational plans.
• Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning.
• Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation.
• Performs real-time on the floor batch record review.
• Interface with cross-functional teams to support facility operations, maintenance activities, and manufacturing objectives.
• Monitor and enforce GMP compliance for all personnel and activities within the Drug Product facility.
• Maintain the facility in an audit-ready state through adherence to procedures, documentation standards, and inspection readiness practices.

Skills

Leadership

Coaching

Communication

Organizational skills

cGMP knowledge

Education

Bachelor's degree in a scientific, technical or engineering discipline

Tools

POMS MES

GMP systems

Job description

Vertex Pharmaceuticals Incorporated in Boston, MA seeks a Supervisor of Manufacturing Operations to lead first, second, or third-shift activities, assign work per schedules, and ensure compliant daily cGMP operations including equipment setup, assembly, operation and cleaning. The role supervises shift personnel and enforces documentation integrity.

The position requires a Bachelor's in a scientific/technical field and 6+ years' experience with supervisory background; prior cell therapy and POMS