Shift Lead, cGMP Manufacturing Operations

Vertex Pharmaceuticals Inc (US); United States; On-site; USD 98,000 - 147,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Paid time off

Job summary

Vertex Pharmaceuticals Inc is seeking a Supervisor, Manufacturing Operations to lead first, second, or third‑shift manufacturing activities. You will assign work, oversee cGMP operations, and ensure compliant, efficient execution of production plans at the Cambridge/Leiden sites.

The role includes real-time batch record reviews, cross‑functional collaboration, and maintaining audit readiness while leading a team through a fast‑paced manufacturing environment.

Qualifications

• Bachelor’s degree in a scientific, technical or engineering discipline.
• 6+ years of experience or equivalent combination of education and experience.
• Prior supervisory or leadership experience preferred.

Responsibilities

• Lead and supervise daily manufacturing operations.
• Assign work to shift personnel based on detailed production schedules and plans.
• Oversee cGMP manufacturing activities including equipment setup, assembly, operation, disassembly, and cleaning.
• Execute and witness batch record instructions during cGMP operations.
• Perform real-time on-the-floor batch record review.
• Interface with cross-functional teams to support facility operations and manufacturing objectives.
• Monitor and enforce GMP compliance for all personnel and activities.
• Maintain audit-ready facility through documentation standards and procedures.

Skills

Leadership

Shift supervision

cGMP knowledge

Batch records

Cross-functional collaboration

Education

Bachelor’s degree in scientific/engineering discipline

Tools

POMS MES

Job description

Vertex Pharmaceuticals Inc is seeking a Supervisor, Manufacturing Operations to lead first, second, or third‑shift manufacturing activities. You will assign work, oversee cGMP operations, and ensure compliant, efficient execution of production plans at the Cambridge/Leiden sites.

The role includes real-time batch record reviews, cross‑functional collaboration, and maintaining audit readiness while leading a team through a fast‑paced manufacturing environment.