RNA Purification & Analytics Lead

System One; Cambridge (MA); On-site; USD 99,000 - 135,000; Full time

Job summary

System One is seeking a Purification & Analytics Scientist for an onsite contract-to-hire role in Boston, MA. You will lead RNA purification and the analytical strategy used to determine batch release.

The position requires a PhD or MS with equivalent experience in analytical chemistry, biochemistry, or bioprocess engineering and a minimum of five years in biologics or nucleic-acid purification and analytical development. This is a demanding role in a growing U.S. biotech organization.

Qualifications

• PhD or MS in analytical chemistry, biochemistry, or bioprocess engineering.
• Minimum of five years of experience in biologics or nucleic-acid purification and analytical development.

Responsibilities

• Lead specialist in RNA purification and analytical strategy to determine batch release
• Manage purification unit operations: tangential flow filtration, membrane or chromatographic purification, including double-stranded RNA removal below 1% w/w and residual DNA below 10 ng/mg
• Develop and maintain the product quality attribute list per modality, mapped to quality-control measurement domains
• Define analytical target profiles for each attribute according to ICH Q2(R2) and Q14, including accuracy, precision, range, and specificity
• Rank and prioritize in-line, at-line, and off-line analytical technologies against established profiles with documented criteria

Education

PhD or MS in analytical chemistry, biochemistry, or bioprocess engineering

Job description

System One is seeking a Purification & Analytics Scientist for an onsite contract-to-hire role in Boston, MA. You will lead RNA purification and the analytical strategy used to determine batch release.

The position requires a PhD or MS with equivalent experience in analytical chemistry, biochemistry, or bioprocess engineering and a minimum of five years in biologics or nucleic-acid purification and analytical development. This is a demanding role in a growing U.S. biotech organization.