RNA Purification Process Development Scientist – DoE & HT

Bristol-Myers Squibb Co; Cambridge (MA); On-site; USD 111,000 - 134,000; Full time

Benefits offered by this job

Flexible Time Off

11 paid holidays

Vacation time 160 hours (new hires)

Volunteer days

Summer hours

Leaves of absence

Global Shutdown

Job summary

Bristol Myers Squibb in Cambridge, MA, is seeking a Scientist for RNA purification process development to design and optimize purification steps for RNA drug substances across development stages. You will execute experiments, build design spaces, and work with upstream/downstream teams to improve yield and purity.

The role emphasizes collaboration, data-rich experimentation, and cross-functional partnerships within a flexible work model.

Qualifications

• BS with 6+ years of science experience.
• MS with 4-6 years of science experience.
• PhD with 0-2 years of science experience.
• Expertise in chromatography, filtration and unit operations.
• Knowledge of DoE and multivariate data analysis.
• Regulatory knowledge (cGMP, ICH) relevant to clinical manufacturing.
• Experience supporting GMP manufacturing and tech transfer.

Responsibilities

• Design, execute, and analyze experiments for existing and novel process modes using DoE and statistical modeling.
• Define the RNA drug substance purification process, the critical parameters, and the design space.
• Experiment using high throughput/automated or data rich experimental setups.
• Design experiments to confirm robust process performance across the control space.
• Collaborate with analytical teams to enable deeper characterization of RNA properties and impurity profiles.
• Collaborate closely with upstream PD to characterize IVT feed stream to maximize RNA yield and purity.
• Prepare technical reports, and communicate findings internally and externally as appropriate.
• Participate in tech transfer activities to GMP manufacturing sites for RNA programs.

Skills

DoE and statistics

Chromatography

Filtration

Multivariate data analysis

Process analytics

RNA chemistry knowledge

cGMP regulatory knowledge

Technical support for clinicalmanufact

Education

BS in Bio/Chemical Engineering or related field

MS in related field

PhD in related field

Tools

HPLC

CE

Gel electrophoresis

Job description

Bristol Myers Squibb in Cambridge, MA, is seeking a Scientist for RNA purification process development to design and optimize purification steps for RNA drug substances across development stages. You will execute experiments, build design spaces, and work with upstream/downstream teams to improve yield and purity.

The role emphasizes collaboration, data-rich experimentation, and cross-functional partnerships within a flexible work model.