Senior Research Associate, Purification

Meet Life Sciences Ltd.; Boston (MA); On-site; USD 85,000 - 120,000; Full time

Job summary

Meet Life Sciences Ltd. in Boston is seeking a Senior Research Associate, Purification, to advance IVT and downstream purification for RNA/xRNA programs in a hands-on lab setting.

You will optimize scale-up, perform AKTA chromatography and TFF steps, and contribute to technology transfer and manufacturing readiness, with strong emphasis on safety and documentation.

Bachelor’s degree with 1–2 years experience or Master with hands-on RNA process development is desired.

Qualifications

• Bachelor's degree with 1–2 years of relevant experience, or Master's with hands-on RNA/xRNA process development
• Hands-on experience with IVT and RNA production processes, including scale-up or tech transfer
• Experience with AKTA chromatography and downstream purification, including TFF and analytical characterization

Responsibilities

• Perform and support IVT reactions at small to intermediate scales using stirred-tank and wave systems
• Troubleshoot and optimize IVT and purification processes to improve performance and support scale-up
• Execute chromatography and purification activities for IVT products using AKTA systems and TFF
• Perform analytical characterization of RNA products (Fragment Analyzer, CE, Bioanalyzer/gel, UV, NanoDrop)
• Maintain documentation and safety compliance while supporting process development and tech transfer

Skills

IVT production

Purification processes

AKTA chromatography

TFF

Analytical characterization

Education

Bachelor's degree in Pharmaceutical Sciences or related

Job description

Senior Research Associate, Purification -- for growing RNA CDMO in Boston

Full-time, permanent, fully onsite role

No visa sponsorship provided at this time

We're partnered with a growing CDMO advancing next-generation RNA therapeutics and drug product manufacturing. As a Senior Research Associate within the Process Sciences team, you will support the development and scale-up of xRNA production processes from laboratory through intermediate scale. This hands-on role will focus on in vitro transcription (IVT), downstream purification, process optimization, and analytical characterization of RNA products. You will work closely with Process Sciences leadership in a collaborative lab and office environment, contributing to both internal programs and client-facing development activities. This is an excellent opportunity for a scientist with hands-on RNA process development experience who wants to build expertise in scalable manufacturing processes and technology transfer.

Job Duties

• Perform and support in vitro transcription (IVT) reactions at small and intermediate scales, including work with stirred-tank and wave-based reaction systems.
• Troubleshoot, optimize, and develop IVT and downstream purification processes to improve process performance and support scale-up activities.
• Execute and support chromatography and purification activities for IVT products, including hands-on work with AKTA purification systems and TFF processes.
• Perform analytical characterization of RNA products, including assessment of purity and concentration using Fragment Analyzer, capillary electrophoresis, Bioanalyzer/gel electrophoresis, UV spectroscopy, and NanoDrop.
• Maintain strong laboratory and documentation practices while supporting process development, technology transfer, and manufacturing activities in accordance with applicable pharmaceutical/biotech and safety requirements.

Requirements

• Bachelor's degree in Pharmaceutical Sciences, Engineering, or a related discipline with 1-2 years of relevant experience, or a Master's degree/equivalent with hands-on experience in mRNA/xRNA or drug substance process development.
• Hands-on experience with IVT and xRNA/mRNA production processes, including process development, optimization, scale-up, and/or technology transfer.
• Practical experience with AKTA chromatography and purification processes, as well as tangential flow filtration (TFF) and downstream process development.
• Experience using analytical characterization techniques and instrumentation including Fragment Analyzer/CE, Bioanalyzer or gel electrophoresis, UV spectroscopy, and NanoDrop.
• Strong written and verbal communication skills, with a solid understanding of laboratory safety practices, BSL requirements, good laboratory practices, and pharmaceutical/biotechnology processes.

Contact

If you're interested, apply to the role. If you would like to connect with Amit directly, email him at [e-mail].