Molecular Biologist (RNA / IVT / DNA Template)

System One; Cambridge (MA); On-site; USD 122,951,000 - 166,345,000; Full time

Job summary

System One in Boston, MA is hiring a Molecular Biologist (RNA/IVT/DNA Template) for a contract‑to‑hire position onsite. The role focuses on bench‑level RNA science under the RNA Bio‑foundry Lead, driving analytical release strategies for batch release.

Compensation is $50.48 per hour with standard business hours and onsite work. The candidate will perform in‑vitro transcription, RNA purification, and DNA template preparation while maintaining strict custody of materials and ensuring high bench

Qualifications

• PhD or MS with five or more years in molecular biology, biochemistry, or a related discipline.
• At least five to eight years of hands‑on RNA work: in‑vitro transcription, capping, poly‑A tailing, RNA purification, and RNA quality analytics.
• Experience with LNP formulation and characterization, and with DNA template preparation.
• Excellent current bench skills and strict material handling in low bioburden/sterile operations.

Responsibilities

• Execute the wet‑laboratory science of the program at the bench, under the Head of RNA Bio‑foundry.
• Perform in‑vitro transcription across four modalities, including capping, poly‑A tailing, circularization chemistry, and guide RNA co‑production.
• Prepare DNA templates and conduct quality control from enzymatic cell‑free synthesis and rolling‑circle amplification processes.
• Conduct in‑process and release analytics: RNA integrity, capping efficiency, poly‑A length, dsRNA content, residual DNA, encapsulation efficiency, and particle characterization.
• Handle modality‑specific starting materials supplied by clinical and pharmaceutical partners, maintaining strict chain of custody.
• Document the primary data behind the de‑risking report and related datasets.

Skills

RNA work

In vitro transcription

RNA purification

LNP formulation

DNA template prep

Benchtop skills

Education

PhD or MS + 5+ years

Job description

Job Title: Molecular Biologist (RNA / IVT / DNA Template)
Location: Boston, MA
Type: Contract to Hire
Compensation:$50.48
Work Model: Onsite
Hours: Standard business hours
Security Clearance: Not specified

Overview: Join a growing U.S. biotechnology organization specializing in RNA medicine manufacturing. In this hands‑on, bench‑based role, you will execute the wet‑laboratory science for the program under the Head of RNA Bio‑foundry, while providing specialist leadership in RNA purification and in developing the analytical release strategy that determines whether each batch can be released.

Responsibilities

• Execute the wet‑laboratory science of the program at the bench, under the Head of RNA Bio‑foundry
• Perform in‑vitro transcription across four modalities, including capping, poly‑A tailing, circularization chemistry, and guide RNA co‑production
• Prepare DNA templates and conduct quality control from enzymatic cell‑free synthesis and rolling‑circle amplification processes
• Conduct in‑process and release analytics: RNA integrity, capping efficiency, poly‑A length, double‑stranded RNA content, residual DNA, encapsulation efficiency, and particle characterization
• Handle modality‑specific starting materials supplied by clinical and pharmaceutical partners, maintaining strict chain of custody
• Document the primary data behind the de‑risking report, the nominal end‑to‑end run baseline, and the multi‑modality demonstration datasets

Requirements

• PhD, or MS with five or more years, in molecular biology, biochemistry, or a related discipline
• At least five to eight years of hands‑on RNA work: in‑vitro transcription, capping, poly‑A tailing, RNA purification, and RNA quality analytics
• Experience with LNP formulation and characterization, and with DNA template preparation
• Excellent current bench skills
• Strong material handling skills and understanding of low bioburden and sterile operations

System One, and its subsidiaries including Joulé and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

#M-#LI-#Ref: #558-Scientific