Scientist III (R&D)

Real Staffing Group; Cambridge (MA); On-site; USD 100,000 - 140,000; Full time

Benefits offered by this job

Health insurance

401(k) plan

Paid time off

Job summary

Real Staffing Group in Cambridge, MA is seeking a Scientist III (R&D) to join its Oligonucleotide/Peptide Purification Development team. The role focuses on developing robust, high-purity purification processes for oligonucleotide and peptide therapeutics for clinical and commercial manufacturing.

You will lead process development and characterization, scale-up unit operations (chromatography, UF/DF), support tech transfer, and contribute to IND submission documents.

Qualifications

• Bachelor’s degree in Biochemistry, Chemical Engineering, or Chemistry with 2–4 years of industry experience.
• Master’s degree with 0–2 years of experience.
• Senior-level candidates require additional experience.

Responsibilities

• Develop and characterize purification processes for oligonucleotide and peptide therapeutics.
• Scale-up unit operations including chromatography and ultrafiltration/diafiltration.
• Support technology transfer activities and troubleshoot on the manufacturing floor.
• Author regulatory sections for IND submissions.
• Mentor new employees and collaborate across teams to improve process understanding.

Skills

Column chromatography

Ion exchange chromatography

Hydrophobic interaction chromatography

Reversed phase chromatography

UF/DF

HPLC

UV spectroscopy

Education

Bachelor's degree in Biochemistry, Chemical Engineering, or Chemistry

Master's degree in life sciences

Tools

AKTA purification systems

Unicorn software

Statistical design/analysis

Job description

A leading organisation is seeking a Scientist III (R&D) to join its Oligonucleotide/Peptide Purification Development team in Cambridge, MA. This onsite role offers the opportunity to contribute to the development of robust, high-purity processes for oligonucleotide and peptide therapeutics, supporting both clinical and commercial manufacturing.

The Scientist III will be responsible for developing and characterising purification processes, including process development, process characterisation, and scale-up for unit operations such as chromatography, detritylation, and ultrafiltration/diafiltration. The role involves learning and advancing oligonucleotide and peptide purification platforms, exploring novel purification steps, and acting as a subject matter expert within cross-functional teams. Responsibilities also include supporting technology transfer activities, troubleshooting on the manufacturing floor, authoring regulatory sections for IND submissions, and leading pilot scale activities. The successful candidate will document laboratory work, mentor new employees, and collaborate across teams to improve process understanding.

Candidates should have a proven record of planning and executing scientific projects, with excellent verbal and written communication skills. Technical proficiency in purification of proteins, peptides, or DNA/RNA using column chromatography (such as ion exchange, hydrophobic interaction, or reversed phase) and ultrafiltration/diafiltration is required. Hands-on experience in analytical techniques, including HPLC and UV/Vis spectroscopy, is preferred. Familiarity with AKTA purification systems, Unicorn software, and statistical design or analysis is advantageous.

Applicants must hold a bachelor's degree in Biochemistry, Chemical Engineering, Chemistry, or a related life science field with 2-4 years of industry experience, or a master's degree with 0-2 years of experience. Senior-level candidates require additional experience as specified.

Must-Have Skills: column chromatography, ion exchange chromatography, hydrophobic interaction chromatography, reversed phase chromatography, UF, DF, HPLC, UV

Nice-to-Have Skills: AKTA purification systems, Unicorn software, statistical design, statistical analysis, process development, process characterization, scale-up, technology transfer, document review, authoring CMC section of, training, mentoring, pilot scale activities, collaboration, time management, Vis spectroscopy

EOE Statement: Specialist Staffing Group is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.

In addition to base pay, employees may be eligible for benefits such as health insurance, health savings accounts, retirement savings plans, life and disability insurance, and paid leave where required by applicable law. Eligibility may vary based on factors such as location and hire date and is subject to change.