Proteomics Research Scientist - Chemical Biology

The Fountain Group; Cambridge (MA); On-site; USD 100,000 - 110,000; Full time

Job summary

The Fountain Group in Cambridge, MA, seeks a Research Scientist specialized in Chemical Biology & Proteomics to apply MS-based proteomics in drug discovery and mechanism-of-action studies. You will design and execute proteomic assays, perform affinity enrichment and proximity biotinylation workflows, and analyze data to investigate protein interactions.

The role involves mammalian cell culture, protein conjugation/purification, UV-Vis characterization, and target validation using cell-based

Qualifications

• Ph.D. in Proteomics, Chemical Biology, Biological Sciences, Biochemistry, or related field with 2+ years hands-on proteomics experience.
• Master's with 1+ year industry proteomics experience and 3–5 years hands-on lab experience.

Responsibilities

• Apply mass spectrometry-based proteomics in drug discovery and mechanism-of-action studies.
• Design and execute proteomic assays, affinity enrichment, and proximity biotinylation workflows.

Skills

Proteomics

Cell culture

Affinity enrichment

Data analysis

Experiment design

Education

Ph.D. or equivalent

Master's with industry proteomics

Tools

LC-MS/MS

Spectronaut

Proteome Discoverer

MaxQuant

Skyline/Xcalibur

Job description

The Fountain Group in Cambridge, MA, seeks a Research Scientist specialized in Chemical Biology & Proteomics to apply MS-based proteomics in drug discovery and mechanism-of-action studies. You will design and execute proteomic assays, perform affinity enrichment and proximity biotinylation workflows, and analyze data to investigate protein interactions.

The role involves mammalian cell culture, protein conjugation/purification, UV-Vis characterization, and target validation using cell-based