Neuroscience Scientist - iPSC & Neuronal Biology

Bristol-Myers Squibb Company; Cambridge (MA); On-site; USD 105,000 - 127,000; Full time

Benefits offered by this job

Wellbeing support

Retirement and financial protection

Medical, dental, vision insurance

Flexible Time Off (FTO)

11 paid holidays

Job summary

Bristol Myers Squibb is seeking a motivated scientist to join the neuroscience exploratory biology group in Cambridge. The role focuses on characterizing disease-relevant biology using primary and iPSC-derived neuronal and glial systems to support target validation and mechanism-of-action studies for early neuroscience programs.

You will design and optimize experiments, culture neuronal systems, validate targets with genome editing, and analyze data to inform project strategy.

Qualifications

• Bachelor's degree in Biology, Neuroscience, Pharmacology, Biochemistry, or related field with 4+ years of experience; or Master's with 2+ years.
• Experience with mammalian cell culture and neurobiology assays is preferred.

Responsibilities

• Design, execute, and troubleshoot experiments to explore neurobiological mechanisms underlying disease-relevant pathways.
• Culture and maintain primary neuronal cultures, iPSC-derived neurons and glia, and other neuroscience-relevant in vitro systems.
• Perform target validation studies, including genome editing and genetic perturbation approaches.
• Conduct mechanism-of-action studies to characterize compound or genetic effects on neuronal and glial biology.
• Apply immunofluorescence, microscopy, and high-content imaging/analysis to assess cellular phenotypes.
• Perform qPCR, JESS, ELISA and MEA to support molecular, biochemical and functional characterization.
• Analyze, document, and present data with rigor and reproducibility; contribute to experimental design discussions.
• Collaborate cross-functionally with computational biology, translational, and drug discovery teams.
• Stay current with neuroscience literature and contribute scientific insight to project strategy.

Skills

Neuroscience expertise

Primary neuronal cultures

iPSC-derived neurons & glia

Genome editing

qPCR

ELISA

Immunofluorescence

High-content imaging

Data analysis

Cross-functional collaboration

Education

Bachelor's degree in Biology, Neuroscience, Pharmacology, Biochemistry, or related field

Master's degree + 2+ years

Tools

JESS

Microscopy

High-content imaging systems

Genome editing tools (CRISPR/Cas9)

Job description

Bristol Myers Squibb is seeking a motivated scientist to join the neuroscience exploratory biology group in Cambridge. The role focuses on characterizing disease-relevant biology using primary and iPSC-derived neuronal and glial systems to support target validation and mechanism-of-action studies for early neuroscience programs.

You will design and optimize experiments, culture neuronal systems, validate targets with genome editing, and analyze data to inform project strategy.