Senior Neuroscience In Vitro Pharmacology Scientist – HTS

Bristol-Myers Squibb Company; Cambridge (MA); Presencial; USD 105.000 - 127.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Flexible Time Off

11 paid company holidays

Global Shutdown between Christmas and?

Descripción de la vacante

Bristol Myers Squibb is seeking a detail-oriented scientist to support high-throughput screening within our neuroscience drug discovery organization in Cambridge. The role focuses on developing and executing scalable assays for compound screening campaigns, driving identification of novel targets and modulators.

Responsibilities include assay development, cell-based screening, genetic perturbation, high-content imaging, and data analysis.

Formación

• Bachelor's degree in Biology, Neuroscience, Pharmacology, Biochemistry, or a related field plus 4+ years of relevant experience; or a Master's degree plus 2+ years of relevant experience.
• Hands-on experience with assay development, compound screening, genetic perturbation, and troubleshooting at scale.
• Proficiency in cell viability and reporter assays, high-content imaging and analysis, and general molecular/cellular assay techniques.
• Familiarity with mammalian cell culture and in vitro models, including neuronal or iPSC-derived cultures is a plus.

Responsabilidades

• Develop, optimize, and validate assays for high-throughput and high-content screening.
• Execute compound screening campaigns including cell viability and reporter-based assays.
• Design and implement genetic perturbation screens (e.g., siRNA/ASO, CRISPR-based).
• Perform high-content imaging and automated image analysis to extract quantitative data.
• Maintain and scale mammalian cell culture systems to support screening throughput.
• Troubleshoot assay performance issues and implement process improvements for data quality and reproducibility.
• Analyze large screening datasets and present results for go/no-go decisions.
• Document protocols and results per scientific and quality standards.
• Collaborate with automation, informatics, and target validation teams to advance screening pipelines.

Conocimientos

High-throughput screening

High-content imaging

Mammalian cell culture

Genetic perturbation screens

CRISPR

siRNA/ASO

Data analysis

Educación

Bachelor's degree in Biology/Neuroscience/Pharmacology/Biochemistry

Master's degree + 2+ years experience

Herramientas

Automation platforms

Image analysis software

Descripción del empleo

Bristol Myers Squibb is seeking a detail-oriented scientist to support high-throughput screening within our neuroscience drug discovery organization in Cambridge. The role focuses on developing and executing scalable assays for compound screening campaigns, driving identification of novel targets and modulators.

Responsibilities include assay development, cell-based screening, genetic perturbation, high-content imaging, and data analysis.