Neuroscience Associate Scientist - Target Validation

Bristol Myers Squibb; Massachusetts; On-site; USD 105,000 - 127,000; Full time

Job summary

Bristol Myers Squibb in Cambridge, MA, is seeking a scientist to join the neuroscience exploratory biology group to characterize disease-relevant biology using primary and iPSC-derived neuronal and glial systems, supporting target validation and mechanism-of-action studies to advance early-stage neuroscience programs.

The role involves designing and executing experiments, maintaining cultures, applying imaging and molecular assays, and collaborating across translational and discovery teams to

Qualifications

• Bachelor's degree with 4+ years of relevant experience or Master's degree with 2+ years of relevant experience.
• Hands-on experience in neuroscience, cell culture, and in vitro systems preferred.
• Experience with genome editing and mechanism-of-action studies is desirable.

Responsibilities

• Design, execute, and troubleshoot experiments to explore neurobiological mechanisms underlying disease-relevant pathways.
• Culture and maintain primary neuronal cultures, iPSC-derived neurons and glia, and other neuroscience-relevant in vitro systems.
• Perform target validation studies, including genome editing and genetic perturbation approaches.
• Conduct mechanism-of-action studies to characterize compound or genetic effects on neuronal and glial biology.
• Apply immunofluorescence, microscopy, and high-content imaging/analysis to assess cellular phenotypes.
• Perform qPCR, JESS, ELISA and MEA to support molecular, biochemical and functional characterization.
• Analyze, document, and present data with rigor and reproducibility; contribute to experimental design discussions.
• Collaborate cross-functionally with computational biology, translational, and drug discovery teams.
• Stay current with neuroscience literature and contribute scientific insight to project strategy.

Skills

Neuroscience

Cell culture

Genome editing

qPCR

ELISA

Immunofluorescence

Microscopy

High-content imaging

Data analysis

Collaboration

Education

Bachelor's degree in Biology/Neuroscience/Pharmacology/Biochemistry or related

Master's degree in related field

Tools

JESS

Microscopy

Job description

Bristol Myers Squibb in Cambridge, MA, is seeking a scientist to join the neuroscience exploratory biology group to characterize disease-relevant biology using primary and iPSC-derived neuronal and glial systems, supporting target validation and mechanism-of-action studies to advance early-stage neuroscience programs.

The role involves designing and executing experiments, maintaining cultures, applying imaging and molecular assays, and collaborating across translational and discovery teams to