Mass Spectrometry Scientist for ADC Bioconjugates

Yoh; Bristol Township (Bucks County); On-site; USD 43,000 - 62,000; Full time

Benefits offered by this job

Medical, Prescription, Dental & Vision

Health Savings Account (HSA)

Life & Disability Insurance

MetLife Voluntary Benefits

Employee Assistance Program (EAP)

401K Retirement Savings Plan

Direct Deposit & weekly epayroll

Referral Bonus Programs

Certification and training opportunity

Job summary

Yoh Life Sciences in Bristol, PA is seeking a Mass Spectrometry Scientist to lead LC-MS method development for conjugates and bioconjugates supporting ADCs, oligonucleotide conjugates, radioconjugates, and related modalities.

The role focuses on developing robust LC-MS workflows, performing DAR analysis, peptide mapping, PTMs, and data interpretation, with responsibilities spanning process development and regulatory support; contract-to-perm, M-F 8-5.

Qualifications

• PhD in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 0 years of industry experience; or MS with 2+ years of relevant experience.
• Experience with intact/reduced, subunit mass analysis, and peptide mapping.
• Extensive hands-on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.
• Hands-on experience with high-resolution mass spectrometry techniques and interpretation of complex datasets.
• Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development.
• Experience with data analysis software such as Waters Connect, MassLynx, or equivalent platforms.

Responsibilities

• Lead development, optimization, and transfer of LC-MS analytical methods supporting ADCs and related bioconjugates.
• Design and execute mass spectrometry studies for characterization of intact proteins/antibodies and related species.
• Perform DAR analysis, peptide mapping, PTM identification, conjugation site analysis, and stability studies.
• Support analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments.
• Develop robust sample preparation workflows for LC-MS analyses of proteins, peptides, oligonucleotides, and conjugated modalities.
• Interpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors.
• Support regulatory submissions including IND, BLA, and IMPD analytical sections.

Skills

LC-MS characterization

High-resolution mass spectrometry

Data analysis software

Protein chemistry

Conjugation technologies

Biopharmaceutical analytics

Education

PhD in Analytical Chemistry or related field

MS in Analytical/biochemical field with 2+ years

Tools

Waters Connect

MassLynx

Job description

Yoh Life Sciences in Bristol, PA is seeking a Mass Spectrometry Scientist to lead LC-MS method development for conjugates and bioconjugates supporting ADCs, oligonucleotide conjugates, radioconjugates, and related modalities.

The role focuses on developing robust LC-MS workflows, performing DAR analysis, peptide mapping, PTMs, and data interpretation, with responsibilities spanning process development and regulatory support; contract-to-perm, M-F 8-5.