Mass Spectrometry Scientist – ADC Bioconjugates Lead

Yoh; Massachusetts; In loco; USD 43.000 - 62.000; Tempo pieno

Vantaggi offerti da questo lavoro

Health benefits

401K Retirement plan

EAP

Direct deposit

Training opportunities

Descrizione del lavoro

Yoh Life Sciences is seeking a Mass Spectrometry Scientist in Bristol, PA to act as a technical expert in LC-MS characterization and method development for ADCs and complex bioconjugates. The role spans process development and CMC activities, with emphasis on DAR, peptide mapping, PTMs, and data interpretation.

The position involves designing workflows for proteins, antibodies, and conjugates, supporting regulatory submissions, and collaborating with cross-functional teams and client sponsors.

Competenze

• PhD in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related field; industry experience preferred or MS with 2+ years.
• Hands-on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.
• Experience with high-resolution MS and interpretation of complex datasets.

Mansioni

• Lead development, optimization, and transfer of LC-MS methods for ADCs and related bioconjugates.
• Design and execute MS studies for intact proteins, antibodies, fragments, peptides, and conjugates.
• Perform DAR analysis, peptide mapping, PTM ID, conjugation site analysis, and stability assessment.
• Support process development, deviations, comparability, and product quality investigations.
• Develop robust sample prep workflows for LC-MS analyses of proteins, peptides, oligos.
• Interpret and communicate findings to cross-functional teams and sponsors.
• Support regulatory submissions including IND, BLA, and IMPD analytical sections.

Conoscenze

LC-MS characterization of biologics/AD

Data analysis software (Waters Connect

Formazione

PhD in Analytical Chemistry or related

MS with 2+ years of relevant experience

Strumenti

Waters Connect

MassLynx

Descrizione del lavoro

Yoh Life Sciences is seeking a Mass Spectrometry Scientist in Bristol, PA to act as a technical expert in LC-MS characterization and method development for ADCs and complex bioconjugates. The role spans process development and CMC activities, with emphasis on DAR, peptide mapping, PTMs, and data interpretation.

The position involves designing workflows for proteins, antibodies, and conjugates, supporting regulatory submissions, and collaborating with cross-functional teams and client sponsors.