Mass Spectrometry Scientist

Yoh; Bristol Township (Bucks County); On-site; USD 43,000 - 62,000; Full time

Benefits offered by this job

Medical, Prescription, Dental & Vision

Health Savings Account (HSA)

Life & Disability Insurance

MetLife Voluntary Benefits

Employee Assistance Program (EAP)

401K Retirement Savings Plan

Direct Deposit & weekly epayroll

Referral Bonus Programs

Certification and training opportunity

Job summary

Yoh Life Sciences in Bristol, PA is seeking a Mass Spectrometry Scientist to lead LC-MS method development for conjugates and bioconjugates supporting ADCs, oligonucleotide conjugates, radioconjugates, and related modalities.

The role focuses on developing robust LC-MS workflows, performing DAR analysis, peptide mapping, PTMs, and data interpretation, with responsibilities spanning process development and regulatory support; contract-to-perm, M-F 8-5.

Qualifications

• PhD in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 0 years of industry experience; or MS with 2+ years of relevant experience.
• Experience with intact/reduced, subunit mass analysis, and peptide mapping.
• Extensive hands-on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.
• Hands-on experience with high-resolution mass spectrometry techniques and interpretation of complex datasets.
• Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development.
• Experience with data analysis software such as Waters Connect, MassLynx, or equivalent platforms.

Responsibilities

• Lead development, optimization, and transfer of LC-MS analytical methods supporting ADCs and related bioconjugates.
• Design and execute mass spectrometry studies for characterization of intact proteins/antibodies and related species.
• Perform DAR analysis, peptide mapping, PTM identification, conjugation site analysis, and stability studies.
• Support analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments.
• Develop robust sample preparation workflows for LC-MS analyses of proteins, peptides, oligonucleotides, and conjugated modalities.
• Interpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors.
• Support regulatory submissions including IND, BLA, and IMPD analytical sections.

Skills

LC-MS characterization

High-resolution mass spectrometry

Data analysis software

Protein chemistry

Conjugation technologies

Biopharmaceutical analytics

Education

PhD in Analytical Chemistry or related field

MS in Analytical/biochemical field with 2+ years

Tools

Waters Connect

MassLynx

Job description

Yoh Life Sciences is hiring for a Mass Spectrometry Scientist in Bristol, PA.

This individual will serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities. The experienced LC-MS scientist will develop LC-MS methods for conjugate characterization activities supporting process development of antibody-drug conjugates (ADCs), oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities.

Position Details

• Position: Mass Spec Scientist


• Duration: contract to perm


• Pay: $40-$45/DOE


• Shift: M-F 8-5pm

Key Responsibilities

• Lead development, optimization, and transfer of LC-MS analytical methods supporting ADCs and related bioconjugate therapeutics.


• Design and execute mass spectrometry studies for characterization of intact proteins/antibodies, fragment antibodies, small format proteins, peptides, linker-payloads, oligonucleotides, and conjugated species.


• Perform characterization activities including DAR analysis, peptide mapping, PTM identification, conjugation site analysis, aggregation and fragmentation assessment, disulfide scrambling, free payload and linker impurity analysis, and stability studies.


• Support analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments.


• Develop robust sample preparation workflows for proteins, peptides, oligonucleotides, and conjugated modalities for LC-MS analyses.


• Interpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors.


• Support regulatory submissions including IND, BLA, and IMPD analytical sections.

Required Qualifications

• Ph.D. in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 0 years of industry experience; or M.S. with 2+ years of relevant experience.


• Experience with analytical characterization techniques including intact/reduced, subunit mass analysis, and peptide mapping.


• Extensive hands‑on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.


• Hands‑on experience with high-resolution mass spectrometry techniques and interpretation of complex datasets.


• Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development.


• Experience with data analysis software such as Waters Connect, MassLynx, or equivalent platforms.

Estimated Min Rate: $31.50

Estimated Max Rate: $45.00

What's In It for You?

Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:

• Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)


• Health Savings Account (HSA) (for employees working 20+ hours per week)


• Life & Disability Insurance (for employees working 20+ hours per week)


• MetLife Voluntary Benefits


• Employee Assistance Program (EAP)


• 401K Retirement Savings Plan


• Direct Deposit & weekly epayroll


• Referral Bonus Programs


• Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

By applying and submitting your resume, you authorize Yoh to review and reformat your resume to meet Yoh's hiring clients' preferences.

To learn more about Yoh's privacy practices, please see our Candidate Privacy Notice: https://www.yoh.com/privacy-notice Stay Safe During Your Job Search

Fraudulent recruiting communications have become increasingly common. Emails from Yoh recruiters will only come from an @yoh.com email address. Yoh will never ask candidates to pay fees, purchase equipment, send gift cards, or transfer funds as part of the recruiting or hiring process. If you receive a communication that appears suspicious or requests payment, contact Yoh directly before responding or sharing personal information.