Senior ADC Separations Scientist - Chromatography Expert

Yoh

Bristol Township (Bucks County)

On-site

USD 48,000 - 69,000

Full time

5 days ago

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Benefits offered by this job

Health benefits

HSA

Life & Disability Insurance

401K Retirement Savings Plan

Direct Deposit & weekly epayroll

Referral Bonus Programs

Certification and training

Job summary

Yoh Life Sciences in Bristol, PA is seeking a Sr. Separations Scientist to serve as technical expert in separations-based characterization and method development across process development and CMC activities.

You will develop advanced chromatographic workflows for structural characterization and impurity analysis to support clinical programs. The role requires PhD with 0 years of industry experience or MS with 2+ years, with extensive hands-on LCUV experience and familiarity with RPLC/UV,

Qualifications

PhD with 0 years of industry experience; MS with 2+ years; BS with 4+ years.
Extensive hands-on LCUV characterization experience.
Experience with analytical characterization techniques including RPLC/UV, SEC-UV, IEX-UV, non-reduced/reduced cIEF.
Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development.
Experience with data analysis software such as Waters Empower or equivalent platforms.

Responsibilities

Lead development, optimization, and transfer of chromatographic analytical methods supporting ADCs and related bioconjugate therapeutics.
Design and execute chromatographic studies for characterization of intact proteins/antibodies, fragment antibodies, small format proteins, peptides, linker-payloads, oligonucleotides, and conjugated species.
Perform characterization activities including DAR analysis, aggregation, fragmentation and charge variant assessment, free payload and linker impurity analysis, and stability studies.
Support analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments.
Collaborate closely with process development, bioassay, formulation, and quality teams to establish analytical control strategies and critical quality attributes (CQAs).
Develop robust sample preparation workflows for proteins, peptides, oligonucleotides, and conjugated modalities for chromatographic analyses.
Interpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors.