Senior Separations Scientist: ADC Characterization

Yoh; Massachusetts; In loco; USD 55.000 - 69.000; Tempo pieno

Descrizione del lavoro

Yoh Life Sciences in Bristol, PA, seeks a Sr. Separations Scientist to lead separations-based characterization and method development across process development and CMC activities.

The role focuses on developing advanced chromatographic workflows for structural characterization, impurity analysis, DAR determination, and comparability studies to support clinical programs. Emphasis on LC/UV techniques and collaboration with QA, formulation, and process development teams.

Competenze

• Ph.D. in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 0 years of industry experience; MS with 2+ years or BS with 4+ years of relevant experience.
• Extensive hands-on experience with LCUV characterization of biologics, ADCs, or related conjugated therapeutics.
• Experience with analytical characterization techniques including RPLC/UV, SEC-UV, IEX-UV, non-reduced/reduced cIEF.
• Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development.
• Experience with data analysis software such as Waters Empower or equivalent platforms.

Mansioni

• Lead development, optimization, and transfer of chromatographic analytical methods supporting ADCs and related bioconjugate therapeutics.
• Design and execute chromatographic studies for characterization of intact proteins/antibodies, fragment antibodies, small format proteins, peptides, linker-payloads, oligonucleotides, and conjugated species.
• Perform characterization activities including DAR analysis, aggregation, fragmentation and charge variant assessment, free payload and linker impurity analysis, and stability studies.
• Support analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments.
• Collaborate closely with process development, bioassay, formulation, and quality teams to establish analytical control strategies and CQAs.
• Develop robust sample preparation workflows for proteins, peptides, oligonucleotides, and conjugated modalities for chromatographic analyses.
• Interpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors.

Formazione

Ph.D. in Analytical Chemistry or related

Strumenti

LCUV characterization

RPLC/UV

SEC-UV

IEX-UV

Descrizione del lavoro

Yoh Life Sciences in Bristol, PA, seeks a Sr. Separations Scientist to lead separations-based characterization and method development across process development and CMC activities.

The role focuses on developing advanced chromatographic workflows for structural characterization, impurity analysis, DAR determination, and comparability studies to support clinical programs. Emphasis on LC/UV techniques and collaboration with QA, formulation, and process development teams.